Association between advanced glycation end products and impaired fasting glucose: results from the SALIA study (Publications)
Advanced glycation end products (AGEs) may contribute to the development of type 2 diabetes and related complications, whereas their role in the early deterioration of glycaemia is unknown. While prev
Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective and efficacious antitrypanosomal strategy (Publications)
The human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality and economic hardship. Drug resistance and toxic side effects of
Malaria eradication and elimination: views on how to translate a vision into reality (Publications)
Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. I
AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa:... (Publications)
BACKGROUND: Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine,
The integrated disease surveillance and response system in northern Ghana: challenges to the core and support functions (Publications)
BACKGROUND: The integrated disease surveillance and response (IDSR) strategy was adopted in Ghana over a decade ago, yet gaps still remain in its proper functioning. The objective of this study was to
Incidence, remission and mortality of convulsive epilepsy in rural Northeast South Africa (Publications)
BACKGROUND: Epilepsy is one of the most common neurological conditions globally, estimated to constitute 0.75% of the global burden of disease, with the majority of this burden found in low- and middl
Use of insecticide quantification kits to investigate the quality of spraying and decay rate of bendiocarb on different wall surfaces in Kagera... (Publications)
BACKGROUND: Bendiocarb was introduced for the first time for Indoor Residual Spraying (IRS) in Tanzania in 2012 as part of the interim national insecticide resistance management plan. This move follow
Effective coverage and systems effectiveness for malaria case management in sub-Saharan African countries (Publications)
Scale-up of malaria preventive and control interventions over the last decade resulted in substantial declines in mortality and morbidity from the disease in sub-Saharan Africa and many other parts of
Maturation and mip-1beta production of cytomegalovirus-specific T cell responses in Tanzanian children, adolescents and adults: impact by HIV and... (Publications)
It is well accepted that aging and HIV infection are associated with quantitative and functional changes of CMV-specific T cell responses. We studied here the expression of Mip-1beta and the T cell ma