Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes (Publications)
This paper describes the discovery of synthetic 1,2,4-trioxolane antimalarials and how we established a workable structure-activity relationship in the context of physicochemical, biopharmaceutical, a
Immunoglobulin kappa light-chain V, J, and C gene sequences of the owl monkey <em>Aotus nancymaae</em> (Publications)
Sequences of Aotus nancymaae immunoglobulin kappa light-chain rearrangements were analyzed after reverse transcription polymerase chain reaction. Among 22 in-frame rearrangements analyzed, 12 IGKV gen
DNA binding affinity of bisguanidine and bis (2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity (Publications)
A new antitrypanosomal hit compound that cures an acute (STIB 900) mouse model of Trypanosoma brucei rhodesiense trypanosomiasis is described. This bis(2-aminoimidazolinium) dicationic compound proved
Short Message Service (SMS) applications for disease prevention in developing countries (Publications)
BACKGROUND: The last decade has witnessed unprecedented growth in the number of mobile phones in the developing world, thus linking millions of previously unconnected people. The ubiquity of mobile ph
Antigenic cross-reactivity between different alleles of the <em>Plasmodium falciparum </em>merozoite surface protein 2 (Publications)
The polymorphic domain of the gene encoding Plasmodium falciparum merozoite surface protein 2 (MSP2) was PCR amplified from blood of malaria patients, genotyped, and 19 distinct fragments were cloned
Skin disorders among school children in rural Tanzania and an assessment of therapeutic needs (Publications)
Eight hundred and twenty primary school children were examined to assess the spectrum and prevalence of skin diseases in rural Tanzania. In all, 55% of the children had one or several skin disorders,