Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual <em>Plasmodium falciparum</em> lysates: evidence for association with... (Publications)
There is longstanding evidence for a role of immunoglobulin (Ig)G in protection against malarial disease and infection. IgG1 and IgG3 have been shown to be particularly efficient at associating with m
Comparison of axillary, rectal and tympanic temperature measurements in children admitted with malaria (Publications)
We compared axillary, rectal and tympanic temperatures in children admitted with severe malaria. The axillary temperatures were 0.74 degrees C (95% limits of agreement -0.85 to 2.33 degrees C) less th
<em>Ex vivo</em> interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of <em>Plasmodium... (Publications)
Thrombospondin-related adhesive protein (TRAP) of Plasmodium falciparum is currently being tested in human vaccine studies. However, its natural reactivity in the field remains poorly characterized. M
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants (Publications)
AIMS: To test the suitability of a simple once daily (OD) gentamicin regimen for use in young infants where routine therapeutic drug monitoring is not possible. METHODS: In an open, randomised, contro
Blood transfusion for severe anaemia in children in a Kenyan hospital [Research letter] (Publications)
Severe anaemia often secondary to malaria is a major contributor to child mortality in sub-Saharan Africa. We have confirmed that use of simple clinical and laboratory criteria can identify those chil
Ocular findings in HIV-1 positive and HIV-1 negative participants in a rural population-based cohort in Uganda (Publications)
PURPOSE: To report the ocular findings in HIV-1 seropositive individuals and HIV-negative controls in a population-based cohort in rural Uganda. METHODS: Participants were examined by an ophthalmologi
Early assessment of the implementation of a national programme for the prevention of mother-to-child transmission of HIV in Cameroon and the effects... (Publications)
OBJECTIVES: To assess the availability of equipment and the staff's knowledge to prevent Mother-To-Child Transmission (PMTCT) in rural healthcare facilities recently covered by the national PMTCT prog
Genetic diversity of <em>Plasmodium falciparum</em> parasites from Kenya is not affected by antifolate drug selection (Publications)
The genotypes of merozoite surface protein-1, merozoite surface protein-2 and glutamine rich protein are frequently used to distinguish recrudescence from reinfection when parasitaemia reappears after
<em>Plasmodium falciparum</em>: in vitro activity of sulfadoxine and dapsone in field isolates from Kenya: point mutations in dihydropteroate synthase... (Publications)
We have determined the relationship between point mutations in the gene that encodes the sulfa target, dihydropteroate synthase (DHPS) and the chemosensitivity profile to sulfadoxine and dapsone in 67