Bronchial hyperresponsiveness and the development of asthma and COPD in asysmptomatic individuals - SAPALDIA cohort study (Publications)
Background: Bronchial hyperresponsiveness (BHR) is a common feature of asthma. However, BHR is also present in asymptomatic individuals and its clinical and prognostic significance is unclear. We hypo
The phenomenon of treatment failures in human African trypanosomiasis (Publications)
Treatment of Human African Trypanosomiasis (HAT or sleeping sickness) relies on a few drugs which are old, toxic and expensive. The most important drug for the treatment of second stage infection is m
Lung function in healthy never smoking adults: reference values and lower limits of normal of a Swiss population (Publications)
BACKGROUND: Reference values and definitions of "normal" are prerequisites for population screening and classification of lung diseases. The aim of this study was to calculate reference values for nev
Medical and economic long-term effects of B-type natriuretic peptide testing in patients with acute dyspnea (Publications)
BACKGROUND: The objective of this prospective study was to assess the medical and economic long-term effects of using B-type natriuretic peptide (BNP) concentrations in the management of patients with
Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from <em>Ancistrocladus cochinchinensis</em>... (Publications)
The first N,8'-coupled naphthylisoquinoline alkaloids with free phenolic OH groups, 4'-O-demethylancistrocladinium A and 6,4'-O-didemethylancistrocladinium A, have been isolated from the leaves and ba
Air pollution and respiratory symptoms in preschool children (Publications)
A diary study on a random sample of 625 Swiss children aged 0 to 5 yr was conducted in two cities in Switzerland to investigate the association between air pollution and respiratory symptoms. Total su
<em>ent</em>-dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the... (Publications)
Three new fully dehydrogenated naphthylisoquinoline alkaloids, the 7,1'-coupled ent-dioncophylleine A (3a), the likewise 7,1'-coupled 5'-O-demethyl-ent-dioncophylleine A (4), and the 7,8'-linked dionc