Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study (Publications)
BACKGROUND: Impaired renal function is evolving as an independent marker of the risk of cardiovascular morbidity and mortality. Little is known about the prevalence of impaired renal function and its
Relative validation of a food frequency questionnaire to estimate food intake in an adult population (Publications)
Background: Scientifically valid descriptions of dietary intake at population level are crucial for investigating diet effects on health and disease. Food frequency questionnaires (FFQs) are the most
A large-scale, consortium-based genomewide association study of asthma (Publications)
BACKGROUND: Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subt
Development of land use regression models for particle composition in twenty study areas in Europe (Publications)
Land Use Regression (LUR) models have been used to describe and model spatial variability of annual mean concentrations of traffic related pollutants such as nitrogen dioxide (NO2), nitrogen oxides (N
Development of land use regression models for PM2.5, PM2.5 absorbance, PM10 and PMcoarse in 20 European study areas; results of the ESCAPE project (Publications)
ABSTRACT Land Use Regression (LUR) models have been used increasingly for modeling small-scale spatial variation in air pollution concentrations and estimating individual exposure for participants of
Prevalence of atopy and respiratory allergic diseases in the elderly SAPALDIA population (Publications)
Background: Because of changing world demographics, the elderly population is steadily increasing. Few studies have assessed the prevalence of atopy and allergic diseases in elderly persons with objec
Circulating alpha1-antitrypsin in the general population: determinants and association with lung function (Publications)
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency associated with low AAT blood concentrations is an established genetic COPD risk factor. Less is known about the respiratory health impact of var
SOS2 and ACP1 loci identified through large-scale exome chip analysis regulate kidney development and function (Publications)
Genome-wide association studies have identified > 50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analy
Determinants of change in airway reactivity over 11 years in a population study (SAPALDIA) (Publications)
We investigated determinants of change in bronchial reactivity in SAPALDIA, a population-based cohort with wide age range (29-72 years at follow-up). The role of sex, age, atopic status, smoking and B
<em>SERPINA1</em> PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort (Publications)
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of