Estimation of malaria parasite reservoir coverage using reactive case detection and active community fever screening from census data with rapid... (Publications)
areas where malaria transmission has been suppressed by vector control interventions many malaria control and elimination programmes are actively seeking new interventions to further reduce malaria prevalence [...] prevalence, incidence and transmission. Malaria infection prevalence and incidence has been shown to cluster geographically, especially at lower transmission levels, and as such a reactive strategy is frequently [...] infections than random searches, but this effect appears to be...
Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis (Publications)
criteria for defining severe malaria have evolved over the last 20 years. We aimed to assess the strength of association of death with features currently characterizing severe malaria through a systematic review [...] Web of Knowledge) were searched to identify publications including African children with severe malaria. PRISMA guidelines were followed. Selection was based on design (epidemiological, clinical and treatment [...] treatment studies), setting (Africa), participants (children < 15...
Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against <em>Schistosoma mansoni</em> (Publications)
development path, hence reducing costs and timelines. Promoting this approach, the Medicines for Malaria Venture (MMV) recently distributed a drug repurposing library of 400 advanced lead candidates (Stasis
GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing (Publications)
Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each replication cycle, some parasites differentiate into gametocytes, the only forms able to infect the mosquito vector [...] vector and transmit malaria. Sexual commitment is triggered by activation of AP2-G, the master transcriptional regulator of gametocytogenesis. Heterochromatin protein 1 (HP1)-dependent silencing of ap2-g
The impact of the scale-up of malaria rapid diagnostic tests on the routine clinical diagnosis procedures for febrile illness: a series of repeated... (Publications)
BACKGROUND: This paper examines the impact of the scale-up of malaria rapid diagnostic tests (RDT) on routine clinical diagnosis procedures for febrile illness in primary healthcare settings in Papua New [...] pre- and post-RDT scale-up and between febrile patients who tested either negative or positive for malaria infection by RDT (post scale-up only). RESULTS: A total of 1809 observations from 120 health facilities [...] scale-up has led to a reduction in body temperature measurement....
Longitudinal estimation of <em>Plasmodium falciparum </em>prevalence in relation to malaria prevention measures in six sub-Saharan African countries (Publications)
(PfPR) is a widely used metric for assessing malaria transmission intensity. This study was carried out concurrently with the RTS,S/AS01 candidate malaria vaccine Phase III trial and estimated PfPR over [...] 3 sites. Surveys were usually performed during the peak malaria parasite transmission season, in one home visit, when medical history and malaria risk factors/prevention measures were collected, and a blood [...] 0.52, 0.68, 0.41) and bed net use in 2 surveys (ORs: 0.63, 0.68, 1.03, 1.78)...
Multiple insecticide resistance in <em>Anopheles gambiae</em> from Tanzania: a major concern for malaria vector control (Publications)
development of insecticide resistance in the major malaria vectors. This study was carried out to monitor the susceptibility status of major malaria vectors to insecticides used for IRS and LLINs in mainland [...] BACKGROUND: Malaria vector control in Tanzania is based on use of long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS), which both rely on the use of chemical insecticides. [...] An. gambiae sensu stricto (s.s.) Kisumu strain. RESULTS: Anopheles arabiensis...
Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite <em>Plasmodium falciparum</em> (Publications)
bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes [...] activation of sexual-stage-specific transcription and gametocyte formation. Our results reveal that malaria parasites can sense and process host-derived physiological signals to regulate differentiation. These [...] of the sexual differentiation pathway in Plasmodium that may provide...
Infant and child mortality in relation to malaria transmission in KEMRI/CDC HDSS, Western Kenya: validation of verbal autopsy (Publications)
(VA) is widely used for estimating malaria specific mortality rates, but does not reliably distinguish malaria from other febrile illnesses. Overall malaria attributable mortality includes both direct and [...] both all-cause and malaria-specific mortality. 48.2% of the deaths could be attributed to malaria by analysing the exposure-response relationship, though only 20.5% of VAs assigned malaria as the cause and [...] BACKGROUND: Malaria transmission reduction is a goal of many malaria control...