Evaluation of the safety and immunogenicity of the RTS,S/AS01E malaria candidate vaccine when integrated in the expanded program of immunization (Publications)
BACKGROUND: The RTS,S/AS01(E) malaria candidate vaccine is being developed for immunization of African infants through the Expanded Program of Immunization (EPI). METHODS: This phase 2, randomized, open [...] registration. ClinicalTrials.gov identifier: NCT00436007 . GlaxoSmithKline study ID number: 106369 (Malaria-050)
<em>In vitro</em> antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria (Publications)
treatment of malaria and associated symptoms. To evaluate the in vitro antiplasmodial efficacy and cytotoxic properties of indigenous medicinal plants used by Venda people against malaria. MATERIALS AND
Surveillance and response strategy in the malaria post-elimination stage: case study of Fujian province (Publications)
Malaria used to be a serious health problem in Fujian province in the past, but no local malaria transmission has been found since 2000. In order to eliminate the potential residual cases and prevent [...] re-introduction of malaria so as to achieve the final goal of malaria elimination in Fujian province, various strategy and intervention approaches were tailored to the local settings. For instance, the [...] respective. All other imported malaria cases were detected during post-elimination...
The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. II. Mortality and morbidity (Publications)
Malaria mortality and morbidity were studied in a rural population of 4000 in the Wosera area, East Sepik Province, Papua New Guinea. Malaria accounted for 4.9% of the 162 deaths investigated by verbal [...] at the beginning of the wet season. The geographical distribution of malaria morbidity was not uniform. The measurement of malaria-related morbidity, the identification of significant seasonal and local [...] verbal autopsy and for 12.2% of the 49 deaths assessed through medical records. Mal...
Lessons from malaria control to elimination: case study in Hainan and Yunnan provinces (Publications)
appears to be victorious in eliminating malaria. However, there is still a long way to go to prevent the reintroduction of malaria in Hainan province and eliminating malaria in the border areas of Yunnan province [...] and P. vivax malaria transmission and the role of an integrated strategy of case management and vector control are compared between different ecological zones. The epidemiology of malaria in Hainan and [...] experiences and challenges from malaria control to elimination in Hainan...
Epigenetic memory takes center stage in the survival strategy of malaria parasites (Publications)
Malaria parasites run through a complex life cycle in the vertebrate host and mosquito vector. This not only requires tightly controlled mechanisms to govern stage-specific gene expression but also ne [...] sexual conversion and discuss the relevance of this strategy for the survival and transmission of malaria parasites.
Asymptomatic malaria infections: detectability, transmissibility and public health relevance (Publications)
even in low-endemic areas. In this Opinion article, we describe the detectability of asymptomatic malaria infections and the relevance of submicroscopic infections for parasite transmission to mosquitoes [...] deployment of molecular diagnostic tools is needed to provide adequate insight into the epidemiology of malaria and infection dynamics to aid elimination efforts