Spatial risk profiling of <em>Plasmodium falciparum</em> parasitaemia in a high endemicity area in Côte d'Ivoire (Publications)
in a high endemicity area of Africa, and to specify how this information can facilitate improved malaria control at the district level. METHODS: A questionnaire was administered to about 4,000 schoolchildren [...] parasitaemia. After accounting for spatial correlation, age, bed net coverage, rainfall during the main malaria transmission season and distance to rivers remained significant covariates. CONCLUSION: It is argued [...] villages in close proximity to rivers, in concert with other...
Innovative tools and OpenHDS for health and demographic surveillance on Rusinga Island, Kenya (Publications)
METHODS: A large trial investigating the effect of odour-baited mosquito traps on malaria vector populations and malaria transmission on Rusinga Island, western Kenya, has deployed an HDSS. By means of [...] DISCUSSION: Adopting innovative technological advancements has enabled the collection of demographic and malaria data quickly and effectively, with minimal margin for errors. Real-time data quality controls integrated
The practical importance of permanent and semipermanent habitats for controlling aquatic stages of <em>Anopheles gambiae</em> <em>sensu lato</em>... (Publications)
aquatic-stage Anopheles is one of the oldest and most historically successful interventions to prevent malaria, but it has seen little application in Africa. Consequently, the ecology of immature afrotropical [...] examine the relative importance and availability of different larval habitats in an area of perennial malaria transmission in preparation for a pilot-scale larval control programme. The study was conducted in [...] types, regardless of permanence. All potential breeding sites need to...
<em>Plasmodium falciparum</em> merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic... (Publications)
allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates. The aim of the current study is to characterize the immune response (epitope [...] (epitope mapping) in naturally exposed individuals and relate immune responses to the risk of clinical malaria. METHODS: To optimize their construction, the fine specificity of human serum antibodies from donors [...] response to individual epitopes within the 3D7 family-specific region...
Estimating the duration of Plasmodium falciparum infection from trials of indoor residual spraying (Publications)
cross-sectional survey data collected from three historical trials of indoor residual spraying against malaria: one from two contiguous districts in Tanzania-Kenya (Pare Taveta) carried out in 1954, the others [...] showed considerable variation but no general age trend. There was also no clear relationship between malaria endemicity and infection duration. Analyses of successive sampling from the same individuals with [...] areas. Periods of several years may be required to evaluate long-term...
Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
Amodiaquine plus artesunate is the recommended antimalarial treatment in many malaria-endemic countries. However, pediatric doses are largely based on a linear extrapolation from adult doses. We pooled [...] amodiaquine, to optimize the dose across all age groups. Adults and children with uncomplicated malaria received daily weight-based doses of amodiaquine or artesunate-amodiaquine over three days. Plasma [...] 22.4% (15.6 - 31.9%) lower at the start of treatment than during convalescence,...
High proportions of asymptomatic and submicroscopic <em>Plasmodium vivax </em>infections in a peri-urban area of low transmission in the Brazilian... (Publications)
regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. [...] conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were [...] carried gametocytes and presented low asexual parasitemia. This reservoir actively...
New algorithm for managing childhood illness using mobile technology (ALMANACH): a controlled non-inferiority study on clinical outcome and antibiotic... (Publications)
INTRODUCTION: The decline of malaria and scale-up of rapid diagnostic tests calls for a revision of IMCI. A new algorithm (ALMANACH) running on mobile technology was developed based on the latest evidence [...] (387%) in control arm were diagnosed with an infection in need for antibiotic, while 38% and 96% had malaria. 815/838 (973%;961-98.4%) were cured at D7 using ALMANACH versus 573/623 (920%;898-941%) using standard
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 7. Dynamics of multiple <em>Plasmodium falciparum </em>infections in infants... (Publications)
The force of infection and recovery rate for malaria in infants in a highly endemic area of Tanzania were analysed using polymerase chain reaction-restriction fragment length polymorphism genotyping of [...] recovery rates were in children under 4 months of age. The higher susceptibility of infants to clinical malaria in comparison with older children, in areas of very high transmission, may be largely a consequence
Trisubstituted pyrimidines as efficacious and fast-acting antimalarials (Publications)
mouse model of malaria. The most promising compound (13) showed a reduction in parasitemia of 96% when dosed at 30 mg/kg orally once a day for 4 days in the P. berghei mouse model of malaria. It also demonstrated