Quality and comparison of antenatal care in public and private providers in the United Republic of Tanzania (Publications)
dispensing prophylactic drugs against anaemia or malaria were not respected, and diagnostic examinations for the assessment of gestation, anaemia, malaria or urine infection were frequently not performed
Genotyping of <em>Plasmodium falciparum</em> infections by PCR: a comparative multicentre study (Publications)
Genetic diversity of malaria parasites represents a major issue in understanding several aspects of malaria infection and disease. Genotyping of Plasmodium falciparum infections with polymerase chain reaction
From magic bullet to magic bomb: reductive bioactivation of antiparasitic agents (Publications)
human cells. Examples are the enzymes of folate synthesis or of the nonmevalonate pathway in the malaria parasites. However, there are other ways how a drug can kill selectively. Of particular relevance [...] the host, as this is how the current frontrunners of parasite chemotherapy work. Artemisinins for malaria, fexinidazole for human African trypanosomiasis, benznidazole for Chagas' disease, metronidazole
Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity (Publications)
The 2-phenoxybenzamide 1 from theMedicines for Malaria Venture Malaria Box Project has shown promising multi-stage activity against different strains of P. falciparum. It was successfully synthesized via
Polyamidoamine nanoparticles for the oral administration of antimalarial drugs (Publications)
mice, slightly improving the activity of the free drug and inducing in the animals immunity against malaria. Liquid chromatography with tandem mass spectrometry analysis of affinity chromatography-purified [...] coinfections such as Plasmodium and Leishmania. When fluorescein-labeled PAAs were fed to females of the malaria mosquito vectors Anopheles atroparvus and Anopheles gambiae, persistent fluorescence was observed
Do bednets including piperonyl butoxide offer additional protection against populations of<em> Anopheles gambiae s.l. </em>that are highly resistant... (Publications)
Malaria control is dependent on the use of longlasting insecticidal nets (LLINs) containing pyrethroids. A new generation of LLINs containing both pyrethroids and the synergist piperonyl butoxide (PBO) [...] (PBO) has been developed in response to increasing pyrethroid resistance in African malaria vectors, but questions remain about the performance of these nets in areas where levels of pyrethroid resistance
Activity refinement of aryl amino acetamides that target the <em>P. falciparum</em> STAR-related lipid transfer 1 protein (Publications)
Malaria is a devastating disease that causes significant morbidity worldwide. The development of new antimalarial chemotypes is urgently needed because of the emergence of resistance to frontline therapies [...] a useful tool for further investigating the druggability of PfSTART1 across the lifecycle of the malaria parasite.
First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: a meta-analysis of... (Publications)
artemisinin combination therapy regimens to treat malaria in early pregnancy are likely to outweigh the adverse outcomes of partially treated malaria, which can occur with oral quinine because of the known [...] safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis [...] antimalarial treatment. METHODS AND FINDINGS: Electronic databases including...
Inference for entomological semi-field experiments: fitting a mathematical model assessing personal and community protection of vector-control... (Publications)
and metofluthrin spatial repellents, as well as combined interventions for Plasmodium falciparum malaria in Anopleles minimus. Overall, all interventions had both personal and community effects, preventing [...] than just reduction in biting, to be parameterised and highlights the tools assessed as promising malaria interventions.
Habitat characterization and spatial distribution of <em>Anopheles </em>sp. mosquito larvae in Dar es Salaam (Tanzania) during an extended dry period (Publications)
INTRODUCTION: By 2030, more than 50% of the African population will live in urban areas. Controlling malaria reduces the disease burden and further improves economic development. As a complement to treated [...] every stagnant open water body, including very polluted ones, have to be considered as potential malaria vector breeding sites