Assessing the variability in experimental hut trials evaluating insecticide-treated nets against malaria vectors (Publications)
Experimental hut trials (EHTs) are used to evaluate indoor vector control interventions against malaria vectors in a controlled setting. The level of variability present in the assay will influence whether
Species composition and insecticide resistance in malaria vectors in Ellibou, southern Côte d’Ivoire and first finding of <em>Anopheles... (Publications)
status of the target vector population is important to guide malaria vector control. The aim of this study was to characterize the malaria vector population in terms of species composition, insecticide [...] an early warning sign, as An. arabiensis shows a different biology than the currently documented malaria vectors. Because the local An. gambiae population was still susceptible to malathion, upregulation
Genetically modified malaria parasites as vaccine candidates (Publications)
Induction of sterile immunity against sporozoite and liver stages of malaria is a long-standing aim in vaccine development. Genetically engineered, attenuated sporozoites were systematically evaluated
A brief history of selected malaria vaccine and medical interventions pursued by the Swiss Tropical and Public Health Institute and partners,... (Publications)
research portfolio as key elements for researching and applying evidence in malaria control and elimination as part of national malaria control programmes. [...] perspective. Its aim is to highlight the above-mentioned transformation by focusing on selected malaria research-cum-action interventions during the crucial period of the 1990s, which were tailored to
Knowledge of antimalarials and health seeking behaviour of households in case of suspected malaria in Democratic Republic of the Congo (Publications)
of the Congo (DRC) is heavily affected by malaria despite availability of effective treatments. Ignorance and unrecommended behaviour toward a suspected malaria case in households may contribute to this [...] urban Health Centres in each of the 11 previous provinces of DRC, all households with a case of malaria in the 15 days prior to the survey were selected. The patient or caregiver (responder) were interviewed [...] predictors of knowledge of recommended antimalarials and adequate behaviour...
Safety, immunogenicity and efficacy of PfSPZ vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase... (Publications)
infection in malaria-naive adults. Preclinical studies show that T cell-mediated immunity is required for protection and is readily induced in humans after vaccination. However, previous malaria exposure can [...] and vaccine efficacy (VE) in adults. We hypothesized that infants with less previous exposure to malaria would have improved immunity and protection. We conducted a multi-arm, randomized, double-blind, [...] tolerability, immunogenicity and efficacy of the PfSPZ Vaccine in infants in a...
Transfluthrin eave-positioned targeted insecticide (EPTI) reduces human landing rate (HLR) of pyrethroid resistant and susceptible malaria vectors in... (Publications)
of transfluthrin eave-positioned targeted insecticide (EPTI) depends on the resistance status of malaria vectors. METHODS: Ribbons treated with 5.25 g transfluthrin or untreated controls were used around
Analysis of contamination in cluster randomized trials of malaria interventions (Publications)
BACKGROUND: In cluster randomized trials (CRTs) of interventions against malaria, mosquito movement between households ultimately leads to contamination between intervention and control arms, unless they [...] which contamination measurably biases the estimate of effectiveness. A sigmoid function is fitted to malaria prevalence or incidence data as a function of the distance of households to the intervention boundary
Effect of interventions to reduce malaria incidence among military personnel on active duty: study protocol for a cluster randomised controlled trial... (Publications)
studies assessing the impact on malaria infection. This study will estimate the protective efficacy of treated uniforms and DEET insect repellent on the incidence of malaria infection among military personnel [...] placebo-controlled trial is planned to evaluate the effectiveness of the interventions on preventing malaria infections in soldiers on active duty at Mgambo National Service Camp in Tanga, Tanzania. The arms [...] untreated uniforms with placebo lotion. The primary outcome is the...
Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S (Publications)
ns. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccine modelling, with a focus on its link to the development of policy guidance for the first licensed