Identification of oleamide in <em>Guatteria</em> recurvisepala by LC/MS-Based <em>Plasmodium falciparum</em> thioredoxin reductase ligand binding... (Publications)
current research on applications of mass spectrometry to natural product drug discovery against malaria aims to screen plant extracts for new ligands to PLASMODIUM FALCIPARUM thioredoxin reductase ( PFTrxR) [...] regulation of the parasite and is validated as a promising target for therapeutic intervention against malaria. In the present study, detannified methanol extracts from GUATTERIA RECURVISEPALA, LICANIA KALLUNKIAE
A 39-amino-acid C-terminal truncation of GDV1 disrupts sexual commitment in<em> Plasmodium falciparum</em> (Publications)
Malaria is a mosquito-borne disease caused by apicomplexan parasites of the genus Plasmodium. Completion of the parasite's life cycle depends on the transmission of sexual stages, the gametocytes, from [...] important to sustain GDV1 protein levels and thereby sexual commitment.IMPORTANCE Transmission of malaria-causing Plasmodium species by mosquitos requires the parasite to change from a continuously growing
Attributes of <em>Anopheles gambiae</em> swarms in South Central Uganda (Publications)
BACKGROUND: Anopheles gambiae continues to be widespread and an important malaria vector species complex in Uganda. New approaches to malaria vector control are being explored including population suppression
New 2‑aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities (Publications)
of sleeping sickness, Trypanosoma brucei rhodesiense, as well as against a causative organism of malaria, Plasmodium falciparum NF54. Their cytotoxic properties were determined with L-6 cells (rat skeletal
Discovery and structure-activity relationships of pyrrolone antimalarials (Publications)
2000-fold) compared to a mammalian cell line (L6), and significant activity against a rodent model of malaria when administered intraperitoneally. Structure-activity relationship studies have indicated ways
Synthesis and antiprotozoal activity of azabicyclo-nonane pyrimidine hybrids (Publications)
protozoan parasites. A series of fused hybrids were synthesized and tested in vitro against pathogens of malaria tropica and sleeping sickness. The activities and selectivities of compounds strongly depended on
Quinuclidine derivatives as potential antiparasitics (Publications)
causative organism of human African trypanosomiasis) and Plasmodium falciparum (a causative agent of malaria), but through an unknown mode(s) of action
Spatial epidemiology in zoonotic parasitic diseases: insights gained at the 1st International Symposium on Geospatial Health in Lijiang, China, 2007 (Publications)
and water-borne helminth infections, as well as arthropod-borne diseases such as leishmaniasis, malaria and lymphatic filariasis. The work made public at this occasion is briefly summarized here to highlight
Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity (Publications)
s and several of their esters have shown promising activity against the causative organisms for malaria and sleeping sickness. The base-catalyzed epimerization of the alcohols was carried out by different
Immunoglobulin kappa light-chain V, J, and C gene sequences of the owl monkey <em>Aotus nancymaae</em> (Publications)
supports the proposal to use the Aotus Plasmodium falciparum infection model for the evaluation of malaria vaccine candidates