Clustering of vector control interventions has important consequences for their effectiveness: a modelling study (Publications)
Vector control interventions have resulted in considerable reductions in malaria morbidity and mortality. When universal coverage cannot be achieved for financial or logistical reasons, the spatial arrangement
Evidence for limited activation of distinct CD4+ T cell subsets in response to the <em>Plasmodium falciparum </em>circumsporozoite protein in Papua... (Publications)
In this study, we have studied cellular and humoral responses of individuals naturally exposed to malaria in a highly endemic region of Papua New Guinea to the circumsporozoite protein of Plasmodium falciparum
Analysis of <em>Plasmodium falciparum</em> infections in a village community in Northern Nigeria: determination of msp2 genotypes and parasitespecific... (Publications)
PNG. The prevalence of IgG antibodies against the circumsporozoite protein (CSP), an indicator for malaria exposure, was over 85% in all age groups showing a high exposure of villagers to P. falciparum. OD
Global metabolic responses of NMRI mice to an experimental <em>Plasmodium berghei</em> infection (Publications)
metabolic profiling may provide a sensitive diagnostic tool of Plasmodium infection and the control of malaria more generally
Insecticide resistance and its association with target-site mutations in natural populations of <em>Anopheles gambiae</em> from eastern Uganda (Publications)
Insecticide resistance in Anopheles gambiae threatens the success of malaria vector control programmes in sub-Saharan Africa. In order to manage insecticide resistance successfully, it is essential to
The reliability of pre-travel history to decide on appropriate counseling and vaccinations: a prospective study (Publications)
history and the effect on advice regarding the administration of vaccines and recommendations for malaria prevention.METHODS: We included prospectively all consenting adults who had not planned an organized
Novel inhibitors of <em>Plasmodium falciparum</em> dihydroorotate dehydrogenase with anti-malarial activity in the mouse model (Publications)
Plasmodium falciparum, the causative agent of the most deadly form of human malaria, is unable to salvage pyrimidines and must rely on de novo biosynthesis for survival. Dihydroorotate dehydrogenase (DHODH)
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 9. Effect of insecticide-treated bed nets on haemoglobin values, prevalence... (Publications)
randomized controlled trial of insecticide-treated bed nets (ITNs) was conducted in an area of high malaria transmission in Tanzania in order to assess the effects of ITNs on infection and anaemia. One hundred
Metabolic, pharmacokinetic, and activity profile of the liver stage antimalarial (RC-12) (Publications)
identified Phase I metabolites had no in vitro activity against P. vivax or P. cynomolgi liver-stage malaria parasites, we suggest that there may be additional unidentified active metabolites of 1 or that the
Isolation and structural elucidation of compounds from <em>Pleiocarpa bicarpellata</em> and their <em>in vitro</em> antiprotozoal activity (Publications)
Species of the genus Pleiocarpa are used in traditional medicine against fever and malaria. The present study focuses on the isolation and identification of bioactive compounds from P. bicarpellata extracts