No fever, no malaria? A diagnostic challenge in an immunocompromised patient (Publications)
women with proven malaria tropicana. Fever was not reported with this patient. We conclude that the concept of using fever as a primary surrogate indicator for the presence of malaria should be used with
Gift from nature: cyclomarin a kills mycobacteria and malaria parasites by distinct modes of action (Publications)
Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a screen [...] enzymesubstrate complex. These results validate PfAp3Aase as a new drug target for the treatment of malaria. We have previously elucidated the structurally unrelated regulatory subunit ClpC1 of the ClpP protease
Progress with <em>Plasmodium falciparum </em>sporozoite (PfSPZ)-based malaria vaccines (Publications)
injectable PfSPZ-based vaccine that provides high grade, durable protection against infection with Pf malaria. Several candidate vaccines are being developed and tested, including PfSPZ Vaccine, in which the [...] and long-term objectives for a final product suitable for mass administration to achieve regional malaria elimination and eventual global eradication
The effect of malaria control on <em>Plasmodium falciparum</em> in Africa between 2000 and 2015 (Publications)
database of malaria field surveys with detailed reconstructions of changing intervention coverage to directly evaluate trends from 2000 to 2015, and quantify the attributable effect of malaria disease control [...] contributor (68% of cases averted). Although still below target levels, current malaria interventions have substantially reduced malaria disease incidence across the continent. Increasing access to these interventions [...] Since the year 2000, a concerted campaign against malaria has...
Mass screening and treatment on the basis of results of a <em>Plasmodium</em> <em>falciparum</em>-specific rapid diagnostic test did not reduce... (Publications)
reaction (PCR) analyses. Data on confirmed malaria infections from health facilities in intervention and hotspot control areas were monitored as proxy for malaria transmission. RESULTS: Approximately 64% [...] carriers) did not reduce subsequent malaria incidence compared with control areas. CONCLUSIONS: Highly sensitive point-of-care diagnostic tools for detection of all human malaria species are needed to make MSAT [...] BACKGROUND: Seasonal increases in malaria continue in hotspots in...
Acquisition of antibodies against <em>Plasmodium falciparum</em> merozoites and malaria immunity in young children: influence of age, force of... (Publications)
levels were not associated with protection from malaria; in contrast, they were typically associated with an increased risk of malaria. Adjustment for malaria exposure, using a novel molecular measure of [...] subclasses) to merozoite antigens and their relationship to the prospective risk of malaria in children aged 1-4yrs in a malaria endemic region of Papua New Guinea. IgG, IgG1 and IgG3 responses generally increased [...] required for protection from malaria. Our results suggest that in...
Histone methyltransferase inhibitors are orally bioavailable, fast acting molecules with activity against different species causing malaria in humans (Publications)
antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite killing activity with the histone
Towards malaria elimination: a new thematic series (Publications)
launch of a new thematic series of Malaria Journal -- "Towards malaria elimination" -- creates the forum that allows carrying scientific evidence on how to achieve malaria elimination in specific endemic
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease (Publications)
In tropical regions, protozoan parasites can cause severe diseases with malaria, leishmaniasis, sleeping sickness, and Chagas disease standing in the forefront. Many of the drugs currently being used to
A research agenda for malaria eradication: modeling (Publications)
Malaria modeling can inform policy and guide research for malaria elimination and eradication from local implementation to global policy. A research and development agenda for malaria modeling is proposed