Nonoperative treatment of splenic rupture in malaria tropica: review of literature and case report (Publications)
In many parts of the world malaria still is a major medical problem. Heavy international and transcontinental traveling carries malaria to non-endemic areas. Practicing physicians must be aware of the [...] the common, but also the rare and severe complications of malaria. During malaria changes in splenic structure can result in asymptomatic enlargement or complications such as hematoma formation, rupture, [...] threatening complication of Plasmodium vivax infection, but is rarely seen in...
Optimization of potent inhibitors of <em>P. falciparum</em> dihydroorotate dehydrogenase for the treatment of malaria (Publications)
dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum [...] but do not inhibit the human enzyme. On the basis of efficacy observed in three mouse models of malaria, acceptable safety pharmacology risk assessment and safety toxicology profile in rodents, lack of
Assessing the impact of malaria interventions on morbidity through a community-based surveillance system (Publications)
programme's impact on the community and health facility burden of malaria and to investigate the value of community-based reporting for routine malaria control programme monitoring. METHODS: This work was implemented [...] data on reported history of fever and severe malaria (convulsions) based on a 2-week recall. In parallel, we collected in-patient and out-patient fever and malaria diagnoses data from the 15 health facilities [...] l decline in the community burden of malaria morbidity between...
Safety and immunogenicity of RTS,S/AS02D malaria vaccine in infants (Publications)
BACKGROUND: The RTS,S/AS malaria vaccine is being developed for delivery through the World Health Organization's Expanded Program on Immunization (EPI). We assessed the feasibility of integrating RTS,S/AS02D [...] The detection of antibodies against Plasmodium falciparum circumsporozoite and efficacy against malaria infection were secondary objectives. RESULTS: At least one serious adverse event was reported in [...] dose of vaccine, the efficacy of the RTS,S/AS02D vaccine against first...
Malaria eradication and elimination: views on how to translate a vision into reality (Publications)
deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and [...] which malaria might eventually be eradicated. Their collective views highlight the challenges and opportunities, and explain how multi-factorial and integrated processes could eventually make malaria eradication
Implementation of the global plan for insecticide resistance management in malaria vectors: progress, challenges and the way forward (Publications)
resistance of malaria vectors to insecticides, particularly to pyrethroids which are widely used in insecticide-treated nets. The Global Plan for Insecticide Resistance Management in malaria vectors (GPIRM) [...] to effective malaria prevention. Aligning efforts and assigning the needed resources will ensure the optimal implementation of GPIRM with the ultimate goal of maintaining effective malaria vector control [...] (GPIRM), released in May 2012, is a collective strategy for the malaria...
Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of seventh biannual meeting (March 2015) (Publications)
reviews or consultations on malaria terminology, malaria in pregnancy, and the feasibility of eradication; as well as updates from the World Health Organization Global Malaria Programme regarding their strategy [...] The Malaria Policy Advisory Committee to the World Health Organization held its seventh meeting in Geneva, Switzerland from 5 to 7 March 2015. This article provides a summary of the discussions, conclusions [...] policy setting processes. Policy statements, position statements, and...