Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid <em>Trypanosoma brucei</em> (Publications)
A whole-organism screen of approximately 87000 compounds against Trypanosoma brucei brucei identified a number of promising compounds for medicinal chemistry optimization. One of these classes of comp
<em>In vitro</em> and<em> In vivo</em> evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness (Publications)
African sleeping sickness is a neglected tropical disease transmitted by tsetse flies. New and better drugs are still needed especially for its second stage, which is fatal if untreated. 28DAP010, a d
Comparing systemic metabolic responses in mice to single or dual infection with <em>Plasmodium berghei</em> and <em>Heligmosomoides bakeri</em> (Publications)
Concomitant infections with Plasmodium and gastrointestinal nematodes are frequently observed in humans. At the metabolic level, the cross-talk between the host and multiple coexisting pathogens is po
Population pharmacokinetics and clinical response for artemether-lumefantrine in pregnant and nonpregnant women with uncomplicated <em>Plasmodium... (Publications)
Artemether-lumefantrine (AL) is the first-line treatment for uncomplicated malaria in the second and third trimesters of pregnancy. Its efficacy during pregnancy has recently been challenged due to al
Sun protective behaviour of vacationers spending holidays in the tropics and subtropics (Publications)
BACKGROUND: The development of malignant melanoma has been associated with intense episodic sun exposure, as it typically occurs during holidays in high ultraviolet (UV)-index countries. OBJECTIVES: T
Ribosomal protein S6 is hyper-activated and differentially phosphorylated in epidermal lesions of patients with psoriasis and atopic dermatitis (Publications)
BACKGROUND: The ribosomal protein S6 (S6) is part of the translation machinery and activated by phosphorylation via the mammalian target of rapamycin (mTOR) pathway, which is activated in psoriatic sk