Pharmacophore model for pentamidine analogs active against <em>Plasmodium falciparum</em> (Publications)
Pentamidine and its analogs constitute a class of compounds that are known to be active against Plasmodium falciparum, which causes the most dangerous malarial infection. Malaria is a widespread disea
Genetic diversity of <em>Mycobacterium tuberculosis</em> in Madang, Papua New Guinea (Publications)
SETTING: Madang and surroundings, Papua New Guinea (PNG). OBJECTIVE: To characterise the genetic diversity and drug susceptibility of Mycobacterium tuberculosis isolates collected in Madang and surrou
The effect of integrated management of childhood illness on observed quality of care of under-fives in rural Tanzania (Publications)
Integrated Management of Childhood Illness (IMCI) has been adopted by over 80 countries as a strategy for reducing child mortality and improving child health and development. It includes complementary
Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar states (Publications)
Background: Copeptin, the C-terminal moiety of provasopressin, is cosecreted with vasopressin. Copeptin may be a useful parameter to characterize disorders of water homeostasis and can be readily meas
Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif (Publications)
Forty-eight cationically substituted pentamidine congeners possessing benzofuran rings were synthesized by a copper mediated heteroannulation of substituted o-iodophenols with phenyl acetylenes. Activ
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story (Publications)
Melarsoprol and pentamidine represent the two main classes of drugs, the arsenicals and diamidines, historically used to treat the diseases caused by African trypanosomes: sleeping sickness in humans