Georatusin, a specific antiparasitic polyketide-peptide hybrid from the gungus <em>Geomyces auratus</em> (Publications)
Georatusin (1), featuring a highly reduced, methylated polyketide moiety fused to a tryptophan by an amide and ester bond forming a 13-membered ring, was produced by the soil fungus Geomyces auratus.
High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds (Publications)
Rapidly spreading antibiotic resistance and the low discovery rate of new antimicrobial compounds demand more effective strategies for early drug discovery. One bottleneck in the drug discovery pipeli
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic... (Publications)
African trypanosomiasis is a neglected parasitic disease that is still of great public health relevance, and a severe impediment to agriculture in endemic areas. The pathogens possess certain unique m
Impact of diagnostic test Xpert MTB/RIF® on health outcomes for tuberculosis (Publications)
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: to assess the impact of Xpert MTB/RIF on important patient outcomes for people with tuberculosis.
On a mission to block transmission (Publications)
The controlled infection of volunteers with Plasmodium falciparum parasites could provide a platform to evaluate new drugs and vaccines aimed at blocking malaria transmission.