Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents (Publications)
The discovery of pyrrolopyrazines as potent antimalarial agents is presented, with the most effective compounds exhibiting EC50 values in the low nanomolar range against asexual blood stages of Plasmo
Cost valuation in resource-poor settings (Publications)
Methods of cost-effectiveness analysis (CEA) have largely been developed for application in Western country settings. Little attention has been paid to the methodological issues in cost valuation in r
Was Wöchnerinnen wünschen: eine qualitative Studie zur häuslichen Wochenbettbetreuung nach der Spitalentlassung durch frei praktizierende Hebammen (Publications)
In Switzerland, decreases in regular hospital treatment after birth are leading increasingly to mother and child being cared for at home by independent midwives. The research herein was carried out in
The morphofunctional characteristics of the ultrastructure of the outer membrane of opisthorchid eggs. 1. The hatching of miracidia (Publications)
Some functional peculiarities of miracidia hatching from O. felineus eggs have been studied, using scanning electron microscope. The results were compared to the earlier data obtained by the method el
Evolution of drug resistance in tuberculosis: recent progress and implications for diagnosis and therapy (Publications)
Drug-resistant tuberculosis is a growing threat to global public health. Recent efforts to understand the evolution of drug resistance have shown that changes in drug-target interactions are only the
Activity of praziquantel enantiomers and main metabolites against <em>Schistosoma mansoni</em> (Publications)
A racemic mixture of R and S enantiomers of praziquantel (PZQ) is currently the treatment of choice against schistosomiasis. Though the S enantiomer and the metabolites are presumed to contribute only
IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo (Publications)
Th17 cells have been recognized as the central effectors in organ-related autoimmune diseases. IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Treg differentiation by inhibition of