Bayesian analysis of zero inflated spatiotemporal HIV/TB child mortality data through the INLA and SPDE approaches: applied to data observed between... (Publications)
Longitudinal mortality data with few deaths usually have problems of zero-inflation. This paper presents and applies two Bayesian models which cater for zero-inflation, spatial and temporal random eff
Bisabololoxide derivatives from <em>Artemisia persica</em>, and determination of their absolute configurations by ECD (Publications)
Five antiplasmodial bisabololoxide sesquiterpene diesters were isolated from an EtOAc extract of the aerial parts of Artemisia persica following an HPLC-time-based activity profiling of the extract. S
Impact of a national HIV voluntary counselling and testing (VCT) campaign on VCT in a rural hospital in Tanzania (Publications)
Summary Objective To evaluate the impact of a national HIV voluntary counselling and testing (VCT) campaign on presentation to HIV care in a rural population in Tanzania. Methods Retrospective analysi
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late stage central nervous system African... (Publications)
We report the discovery of novel boron-containing molecules, exemplified by N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl-2-trifluoromethylbenzam ide (AN3520) and 4-Fluoro-N-(1-hydroxy-1,3-dihydr
Bis(oxyphenylene)benzimidazoles: a novel class of anti-<em>Plasmodium falciparum</em> agents (Publications)
A small library of 26 2,2'-[alkane-alpha,omega-diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhode
Antiparasitic agents: new drugs on the horizon (Publications)
The need for new drugs against tropical parasites such as Plasmodium falciparum and Trypanosoma brucei is persistent since problems with resistance and toxicity are jeopardizing the currently availabl
Induction of parasite growth-inhibitory antibodies by a virosomal formulation of a peptidomimetic of loop I from domain III of <em>Plasmodium... (Publications)
Apical membrane antigen 1 (AMA-1) of Plasmodium falciparum is a leading candidate antigen for inclusion in a malaria subunit vaccine. Its ectodomain can be divided into three subdomains, each with dis
Force of infection is key to understanding the epidemiology of <em>Plasmodium falciparum</em> malaria in Papua New Guinean children (Publications)
Genotyping Plasmodium falciparum parasites in longitudinal studies provides a robust approach to estimating force of infection (FOI) in the presence of superinfections. The molecular parameter (mol)FO