Chemotherapy for major food-borne trematodes: a review (Publications)
Food-borne trematode infections, caused by liver flukes (Clonorchis, Fasciola, Opisthorchis), lung flukes (Paragonimus) and intestinal flukes (Echinostoma, Fasciolopsis, heterophyids), are significant
Activity of artemether and mefloquine against juvenile and adult <em>Schistosoma mansoni</em> in athymic and immunocompetent NMRI mice (Publications)
Immune effector mechanisms can enhance the activity of antischistosomal drugs. We examined the in vivo effect of single oral doses of the antimalarials artemether (400 mg/kg) and mefloquine (200 mg/kg
Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with <em>Fasciola hepatica</em> (Publications)
OBJECTIVES: The pharmacokinetic (PK) parameters of artesunate, recently discovered to possess promising trematocidal activity, and its main metabolite dihydroartemisinin (DHA) were determined in rats
Trypanocidal, leishmanicidal and cytotoxic effects of anthecotulide-type linear sesquiterpene lactones from Anthemis auriculata (Publications)
Trypanosomiasis and leishmaniasis pose major public health threats for many countries, particularly those in sub-Saharan Africa and South America. In the present study, we evaluated the in vitro antip
Discovery of dual function acridones as a new antimalarial chemotype (Publications)
Preventing and delaying the emergence of drug resistance is an essential goal of antimalarial drug development. Monotherapy and highly mutable drug targets have each facilitated resistance, and both a
Liver morbidity due to <em>Schistosoma mekongi</em> in Cambodia after seven rounds of mass drug administration (Publications)
Severe liver disease due to Schistosoma mekongi was frequent in northern Cambodia. Between 1995 and 2002, seven rounds of mass chemotherapy (praziquantel) reduced infection from 50% to below 3%. In 20
Activity of antiandrogens against juvenile and adult <em>Schistosoma mansoni </em>in mice (Publications)
Objectives The antischistosomal properties of the marketed antiandrogens bicalutamide, flutamide, nilutamide and cyproterone acetate were studied both in vivo and in vitro. Methods Schistosoma mansoni