Efficacy of the cyclooctadepsipeptide PF1022A against <em>Heligmosomoides bakeri in vitro</em> and <em>in vivo</em> (Publications)
SUMMARYThe cyclooctadepsipeptide PF1022A derived from the fungus, Mycelia sterilia, is characterized by a broad spectrum of activity against different parasitic gastrointestinal nematodes of livestock
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug... (Publications)
Drug resistance against dihydrofolate reductase (DHFR) inhibitors-such as pyrimethamine (PM)-has now spread to almost all regions where malaria is endemic, rendering antifolate-based malaria treatment
Estimation of the sequestered parasite load in severe malaria patients using both host and parasite markers (Publications)
The virulence of the malaria parasite Plasmodium falciparum is due, in part, to its ability to cytoadhere in deep vascular beds. Our inability to quantify the load of sequestered parasites hampers our
Global goods movement and the local burden of childhood asthma in southern California (Publications)
OBJECTIVES: As part of a community-based participatory research effort, we estimated the preventable burden of childhood asthma associated with air pollution in the southern California communities of
Alcohol consumption and other lifestyle factors: avoidable sources of excess lead exposure (Publications)
Lead concentration in whole blood of a representative sample of 471 subjects aged 20 to 74 years and living in Basle was determined in 1989/90 by flame atomic absorption spectrophotometry. The partici
Interferons direct an effective innate response to Legionella pneumophila infection (Publications)
Legionella pneumophila remains an important opportunistic pathogen of human macrophages. Its more limited ability to replicate in murine macrophages has been attributed to redundant innate sensor syst
Non-Hodgkin lymphoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy (Publications)
OBJECTIVE: To assess the long-term effect of HAART on non-Hodgkin lymphoma (NHL) incidence in people with HIV (PHIV). DESIGN: Follow-up of the Swiss HIV Cohort Study (SHCS). METHODS: Between 1984 and