Modelling the cost-effectiveness of mass screening and treatment for reducing <em>Plasmodium falciparum</em> malaria burden (Publications)
BACKGROUND: Past experience and modelling suggest that, in most cases, mass treatment strategies are not likely to succeed in interrupting Plasmodium falciparum malaria transmission. However, this doe
Paediatric referrals in rural Tanzania: the Kilombero District Study - a case series (Publications)
BACKGROUND: Referral is a critical part of appropriate primary care and of the Integrated Management of Childhood Illness (IMCI) strategy. We set out to study referrals from the aspect both of primary
The interrelation between premenstrual syndrome and major depression: results from a population-based sample (Publications)
ABSTRACT: BACKGROUND: Research about the relationship between premenstrual syndrome (PMS) and major depression is limited. This study examined the relationship between moderate to severe PMS and major
Viral hepatitis and rapid diagnostic test based screening for HBsAg in HIV-infected patients in rural Tanzania (Publications)
BACKGROUND: Co-infection with hepatitis B virus (HBV) is highly prevalent in people living with HIV in Sub-Saharan Africa. Screening for HBV surface antigen (HBsAg) before initiation of combination an
Simulated impact of RTS,S/AS01 vaccination programs in the context of changing malaria transmission (Publications)
INTRODUCTION: The RTS,S/AS01 pre-erythrocytic malaria vaccine is in phase III clinical trials. It is critical to anticipate where and how it should be implemented if trials are successful. Such planni
Frontiers of parasitology research in the People's Republic of China: infection, diagnosis, protection and surveillance (Publications)
ABSTRACT: Control and eventual elimination of human parasitic diseases in the People's Republic of China (P.R. China) requires novel approaches, particularly in the areas of diagnostics, mathematical
Time to move from presumptive malaria treatment to laboratory-confirmed diagnosis and treatment in African children with fever (Publications)
BACKGROUND TO THE DEBATE: Current guidelines recommend that all fever episodes in African children be treated presumptively with antimalarial drugs. But declining malarial transmission in parts of sub
On the origin of <em>Mycobacterium ulcerans</em>, the causative agent of Buruli ulcer (Publications)
ABSTRACT: BACKGROUND: Mycobacterium ulcerans is an unusual bacterial pathogen with elusive origins. While closelyrelated to the aquatic dwelling M. marinum, M. ulcerans has evolved the ability to prod
Implementing new health interventions in developing countries: why do we lose a decade or more? (Publications)
BACKGROUND: It is unclear how long it takes for health interventions to transition from research and development (R&D) to being used against diseases prevalent in resource-poor countries. We undertook