Synthesis and in vitro and in vivo evaluation of antimalarial polyamines (Publications)
We recently reported that 1,14-diphenylacetamide derivatives of spermine exhibit potent nM in vitro growth inhibition properties of Plasmodium falciparum. In an effort to expand the structure-activity
Economics of brucellosis impact and control in low-income countries (Publications)
Most data and evidence on the economic burden of brucellosis and the benefits of its control are from high-income and middle-income countries. However, the burden of brucellosis is greatest in low-inc
Cold extremities and difficulties initiating sleep: evidence of co-morbidity from a random sample of a Swiss urban population (Publications)
Difficulties initiating sleep (DIS) can frequently occur in psychiatric disorders but also in the general population. The primary vasospastic syndrome is a functional disorder of vascular regulation i
Estimating malaria transmission through mathematical models (Publications)
Evaluating the effectiveness of malaria control interventions on the basis of their impact on transmission is increasingly important as countries move from malaria control to pre-elimination programs.
Pharmacokinetics, <em>Trypanosoma brucei gambiense</em> efficacy and time of drug action of DB829, a preclinical candidate for treatment of second... (Publications)
Human African trypanosomiasis (HAT, sleeping sickness), a neglected tropical disease endemic to sub-Saharan Africa, is caused by the parasites Trypanosoma brucei (T. b.) gambiense and T. b. rhodesiens
Patients routinely report more symptoms to experienced field enumerators than physicians in rural Côte d'Ivoire (Publications)
Medical history-taking is among the most powerful diagnostic tools for healthcare professionals. However, its accuracy and reliability are underexplored areas. The present post-hoc study compares medi
Cotton dust, endotoxin and cancer mortality among the Shanghai textile workers cohort: a 30-year analysis (Publications)
BACKGROUND: Although occupational exposure to cotton dust and endotoxin is associated with adverse respiratory health, associations with cancer are unclear. We investigated cancer mortality in relatio
Missed opportunities among HIV-positive women to control viral replication during pregnancy and to have a vaginal delivery (Publications)
INTRODUCTION:: Most national guidelines for the prevention of mother-to-child transmission of HIV in Europe updated between 2001 and 2010 recommend vaginal deliveries for women with undetectable or ve
Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects... (Publications)
BACKGROUND: Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European popula
Prevalence of drug-resistance mutations and HIV-1 subtypes in a HIV-1 infected COHORT in rural Tanzania (Publications)
ABSTRACT The development of resistance mutations in drug-targeted HIV-1 genes compromises the success of antiretroviral therapy (ART) programmes. Genotyping of these mutations enables adjusted therape