Prospects for dog rabies elimination in Nigeria by 2030 (Publications)
The attainment of the global target of zero dog-mediated human rabies by 2030 depends on functional rabies programmes. Nigeria, a rabies-endemic country, and the most populous country in Africa has a
High incidence of catheter-associated urinary tract infections and related antibiotic resistance in two hospitals of different geographic regions of... (Publications)
OBJECTIVE: Catheter-associated urinary tract infections (CAUTI) are common worldwide, but due to limited resources, its actual burden in low-income countries is unknown. Currently, there are gaps in k
Antibiotic use and consumption among medical patients of two hospitals in Sierra Leone: a descriptive report (Publications)
BACKGROUND: Although one of the main drivers of antimicrobial resistance is inappropriate antibiotic prescribing, there are limited resources to support the surveillance of antibiotic consumption in l
Metabolic characterization of <em>Leishmania major</em> infection in activated and nonactivated macrophages (Publications)
Infection with Leishmania spp. can lead to a range of symptoms in the affected individual, depending on underlying immune-metabolic processes. The macrophage activation state hereby plays a key role.
Metabolic, immune, and gut microbial signals mount a systems response to <em>Leishmania major</em> infection (Publications)
Parasitic infections such as leishmaniasis induce a cascade of host physiological responses, including metabolic and immunological changes. Infection with Leishmania major parasites causes cutaneous l
Metabolism of (<em>R</em>)-praziquantel versus the activation of a Parasite Transient Receptor Potential Melastatin ion channel (Publications)
Praziquantel (PZQ) is an essential anthelmintic drug recently established to be an activator of a Transient Receptor Potential Melastatin (TRPM(PZQ) ) ion channel in trematode worms. Bioinformatic, mu
Opportunities and challenges for decentralised clinical trials in sub-Saharan Africa: a qualitative study (Publications)
INTRODUCTION: Digital health has gained traction in research and development, and clinical decision support systems. The COVID-19 pandemic accelerated the adoption of decentralised clinical trials (DC
Antibody and B cell responses to SARS-CoV-2 infection and vaccination: the end of the beginning (Publications)
As the COVID-19 pandemic has evolved during the past years, interactions between human immune systems, rapidly mutating and selected SARS-CoV-2 viral variants, and effective vaccines have complicated