<em>Ex vivo</em> interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of <em>Plasmodium... (Publications)
Thrombospondin-related adhesive protein (TRAP) of Plasmodium falciparum is currently being tested in human vaccine studies. However, its natural reactivity in the field remains poorly characterized. M
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants (Publications)
AIMS: To test the suitability of a simple once daily (OD) gentamicin regimen for use in young infants where routine therapeutic drug monitoring is not possible. METHODS: In an open, randomised, contro
Blood transfusion for severe anaemia in children in a Kenyan hospital [Research letter] (Publications)
Severe anaemia often secondary to malaria is a major contributor to child mortality in sub-Saharan Africa. We have confirmed that use of simple clinical and laboratory criteria can identify those chil
Genetic diversity of <em>Plasmodium falciparum</em> parasites from Kenya is not affected by antifolate drug selection (Publications)
The genotypes of merozoite surface protein-1, merozoite surface protein-2 and glutamine rich protein are frequently used to distinguish recrudescence from reinfection when parasitaemia reappears after
HIV-1 RNA levels in an African population-based cohort and their relation to CD4 lymphocyte counts and World Health Organization clinical staging (Publications)
Apart from a small number of reports from people who are based in hospitals, data on viral load in HIV-infected people in sub-Saharan Africa, where most infections occur, are lacking. We report serum
The effects of untreated bednets on malaria infection and morbidity on the Kenyan coast (Publications)
A study was conducted in order to determine whether children that slept under untreated bednets were protected against both malaria infection and clinical disease compared with children not sleeping u
Relationship between HIV-1 Env subtypes A and D and disease progression in a rural Ugandan cohort (Publications)
OBJECTIVE: To investigate the role of HIV-1 envelope subtypes on disease progression in a rural cohort of Ugandan adults where two major HIV-1 subtypes (A and D) exist. METHODS: Participants of a clin
<em>Plasmodium falciparum</em> infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy... (Publications)
Antibodies to the highly diverse variant surface antigens (VSAs) expressed on Plasmodium falciparum-infected erythrocytes are thought to play a role in the development of naturally acquired immunity t
<em>Plasmodium falciparum</em>-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age (Publications)
The variant surface antigens (VSAs) of Plasmodium falciparum-infected red blood cells are potentially important targets of naturally acquired immunity to malaria. Natural infections induce agglutinati