Peak flow variability in the SAPALDIA study and its validity in screening for asthma-related conditions (Publications)
We used 3-wk peak expiratory flow (PEF) measurements (twice daily) made in the diary study of the population-based Swiss Study on Air Pollution and Lung Disease in Adults to describe PEF-variability (
Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 european cohorts (Publications)
BACKGROUND: Air pollution has been associated with cardiovascular mortality, but it remains unclear as to whether specific pollutants are related to specific cardiovascular causes of death. Within the
A large-scale, consortium-based genomewide association study of asthma (Publications)
BACKGROUND: Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subt
Development of land use regression models for particle composition in twenty study areas in Europe (Publications)
Land Use Regression (LUR) models have been used to describe and model spatial variability of annual mean concentrations of traffic related pollutants such as nitrogen dioxide (NO2), nitrogen oxides (N
Development of land use regression models for PM2.5, PM2.5 absorbance, PM10 and PMcoarse in 20 European study areas; results of the ESCAPE project (Publications)
ABSTRACT Land Use Regression (LUR) models have been used increasingly for modeling small-scale spatial variation in air pollution concentrations and estimating individual exposure for participants of
Health-related quality of life and risk factors associated with spirometric restriction (Publications)
The restrictive spirometric pattern is associated with a substantial morbidity and mortality burden. We sought to determine to what extent spirometric restriction is associated with impaired quality o
Prevalence of atopy and respiratory allergic diseases in the elderly SAPALDIA population (Publications)
Background: Because of changing world demographics, the elderly population is steadily increasing. Few studies have assessed the prevalence of atopy and allergic diseases in elderly persons with objec
Circulating alpha1-antitrypsin in the general population: determinants and association with lung function (Publications)
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency associated with low AAT blood concentrations is an established genetic COPD risk factor. Less is known about the respiratory health impact of var
Determinants of change in airway reactivity over 11 years in a population study (SAPALDIA) (Publications)
We investigated determinants of change in bronchial reactivity in SAPALDIA, a population-based cohort with wide age range (29-72 years at follow-up). The role of sex, age, atopic status, smoking and B
<em>SERPINA1</em> PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort (Publications)
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of