Tribendimidine and albendazole for treating soil-transmitted helminths, <em>Strongyloides stercoralis</em> and <em>Taenia</em> spp.: open-label... (Publications)
point to activity against cestodes and Strongyloides ratti. METHODOLOGY/PRINCIPAL FINDINGS: In an open-label randomized trial, the safety and efficacy of a single oral dose of albendazole or tribendimidine
Single-center outcome analysis of 1,161 patients with St. Jude medical and ATS open pivot mechanical heart valves (Publications)
BACKGROUND AND AIM OF THE STUDY: The clinical performance of mechanical heart valves and valve-related complications are important safety endpoints in patients after heart valve replacement. In this r
Eleven-year single-center experience with the ATS Open Pivot Bileaflet heart valve (Publications)
BACKGROUND: The ATS Open Pivot Heart Valve was first introduced in 1992 and has been implanted routinely at our institution since 1993. Valve selection was based on surgeon preference. The objective of [...] 11-year experience demonstrates low rates of adverse events and valve-related complications with the ATS Open Pivot heart valve
In Tanzania, the many costs of pay-for-performance leave open to debate whether the strategy is cost-effective (Publications)
Pay-for-performance programs in health care are widespread in low- and middle-income countries. However, there are no studies of these programs' costs or cost-effectiveness. We conducted a cost-effect
Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis... (Publications)
BACKGROUND: New antituberculosis regimens are urgently needed to shorten tuberculosis treatment. Following on from favourable assessment in a 2 week study, we investigated a novel regimen for efficacy
Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids (Publications)
Phenotypic screening had successfully been used for hit generation, especially in the field of neglected diseases, in which feeding the drug pipeline with new chemotypes remains a constant challenge.
Microbial contamination along the main open wastewater and storm water channel of Hanoi, Vietnam, and potential health risks for urban farmers (Publications)
The use of wastewater in agriculture and aquaculture has a long tradition throughout Asia. For example, in Hanoi, it creates important livelihood opportunities for > 500,000 farmers in peri-urban comm
Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against <em>Schistosoma haematobium</em>: randomized,... (Publications)
properties, yet no clinical studies have been performed. METHODS: We conducted a randomized, exploratory open-label trial to assess the efficacy and safety of mefloquine (25 mg/kg), artesunate (3 doses of 4 mg/kg)