Global Malaria Technical & Training Support Package, Phase 4 (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/global-malaria-technical-training-support-package-phase-4
control, case management (malaria treatment) and cross-sectoral action against malaria, and through the training of malaria affected countries’ scientists and national malaria control managers. GlobMal [...] strategic direction towards the ambitious 2030 malaria goals to reduce malaria mortality by 40% by 2020 (compared with 2015) and to increase the number of malaria-free countries by additional 10 and 35 countries [...] contribute to global malaria control and elimination by shaping global and...
PATH - MVI Malaria Vaccine Modeling: Service Agreement (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/path-mvi-malaria-vaccine-modeling-service-agreement
Swiss TPH is carrying out simulations of the public health impact of the RTS,S malaria vaccine, with the support of PATH-MVI. The work involves simulation of the impact of adding vaccines in the context [...] countries in sub-Saharan Africa, taking into account contextual factors such as the distributions of malaria transmission intensities. Vaccine profiles are based on field data from Phase III trials of RTS,S
Clinical Performance Evaluation and Cost-Effectiveness Analysis of miLab platform for Supporting Malaria Control in Target Countries (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/clinical-performance-evaluation-and-cost-effectiveness-analysis-of-milab-platform-for-supporting-malaria-control-in-target-countries
samples. The platform is of potential high interested for malaria control, namely malaria diagnostics in low- and middle-income countries, as malaria remains a major cause of morbidity and mortality in large [...] compared to the current routine malaria diagnostic in the field. The impact evaluation will also assess whether and how the use of miLab contributes to an improved malaria case detection workflow in two
Characterization of field malaria isolates and assessment of the impact of resistance profile on the transmission of resistant strains (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/characterization-of-field-malaria-isolates-and-assessment-of-the-impact-of-resistance-profile-on-the-transmission-of-resistant-strains
field malaria parasites, in order to provide a more realistic representation of malaria transmission occurring in natural settings. We will establish a continuous culture protocol for field malaria parasite [...] Health Institute (IHI, Tanzania). Malaria elimination is threatened by resistance to current insecticides and antimalarials. Developing novel technologies that target malaria transmission, such as transmission [...] transmission blocking drugs, vaccines or insecticides to control malari...
Evaluation of the Community-Based Malaria Surveillance and Response in Rwanda (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/evaluation-of-the-community-based-malaria-surveillance-and-response-in-rwanda
sustaining malaria elimination. Today, most of malaria control strategies rely on passive case detection through health facilities and CHWs. This passive case detection forms the foundation of malaria surveillance [...] approach will help Rwanda malaria control program to improve the deployment of interventions, and ultimately sustain the gains in malaria declines towards the achievement of malaria elimination in Rwanda. [...] proportion of malaria infections will not take the attention of...
Genome-wide analysis of variations in Plasmodium falciparum parasites population and their impact on different malaria interventions in Tanzania (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/genome-wide-analysis-of-variations-in-plasmodium-falciparum-parasites-population-and-their-impact-on-different-malaria-interventions-in-tanzania
Malaria affects millions of people globally, and the disease remains one of the major public health problems occurring in most parts of the world, causing thousands of deaths each year, especially among
Exploring early sexual differentiation in the malaria parasite Plasmodium falciparum (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/exploring-early-sexual-differentiation-in-the-malaria-parasite-plasmodium-falciparum
Apicomplexa, is the causative agent of the most severe form of malaria in humans. Despite the massive implementation of control interventions, malaria still causes over 200 million clinical cases and half a million [...] million deaths annually. The widespread prevalence of malaria in endemic regions is maintained by a complex yet highly efficient transmission cycle between the human host and mosquito vector. For transmission [...] gametocyte biology will be essential to support the development...
Core Malaria Modelling (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/core-malaria-modelling
and use of an individual-based model of malaria transmission dynamics known as OpenMalaria. This model is an open-source tool for simulating the dynamics of malaria transmission and epidemiology, and the [...] and economic outcomes. The opensource code and details of our model OpenMalaria can be found here . The model can simulate malaria in village or district size human populations, and has been used to address [...] TPH, our OpenMalaria model is used by a wide range of modellers worldwide....