Efficacy and safety of fexinidazole in patients with Human African Trypanosomiasis (HAT) due to Trypanosoma brucei rhodesiense: a multicentre,... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/efficacy-and-safety-of-fexinidazole-in-patients-with-human-african-trypanosomiasis-hat-due-to-trypanosoma-brucei-rhodesiense-a-multicentre-open-label-clinical-trial
A vector-borne parasitic illness, human African trypanosomiasis (HAT), also known as sleeping sickness, is usually fatal without treatment. The less prevalent form, T.b. rhodesiense (r-HAT), is concen
Evolution and Epidemiology of Rifampicin-Resistant Tuberculosis in Khayelitsha, Cape Town: Implications for Biology and Disease Control (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/evolution-and-epidemiology-of-rifampicin-resistant-tuberculosis-in-khayelitsha-cape-town-implications-for-biology-and-disease-control
Background Bacteria resistant to multiple antibiotics are a growing threat for global public health and the economy. Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant TB (XDR-TB
Drug discovery and development for schistosomiasis: From repositioning of antimalarial drug leads and clinical advanced drug candidates to the... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/drug-discovery-and-development-for-schistosomiasis-from-repositioning-of-antimalarial-drug-leads-and-clinical-advanced-drug-candidates-to-the-development-of-a-new-paediatric-formulation-of-praziquantel
The aim of my 4-year research project is to identify one or several antischistosomal drug development candidates targeting the haemoglobin degradation pathway and/or other mechanisms with favourable p
Analysing in-hospital mortality and morbidity in Côte d’Ivoire: implications for HIV/Aids, Malaria and TB (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/analysing-in-hospital-mortality-and-morbidity-in-cote-divoire-implications-for-hiv/aids-malaria-and-tb
sAnalysing routine data from health facilities across the country, the study intends to analyse trends in mortality and morbidity for HIV/Aids, Malaria and TB between 2010-2015. The Swiss TPH provides
Efficacy and safety of moxidectin plus albendazole, moxidectin plus tribendimidine, albendazole plus oxantel pamoate and moxidectin alone against... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/efficacy-and-safety-of-moxidectin-plus-albendazole-moxidectin-plus-tribendimidine-albendazole-plus-oxantel-pamoate-and-moxidectin-alone-against-trichuris-trichiura-and-concomitant-soil-transmitted-helminth-infections-a-randomized-controlled-trial
The recommended anthelmintics show low efficacy in a single-dose regimen against Trichuris trichiura. Moxidectin, a new treatment for river blindness, might complement the drug armamentarium for the t
Infected body on a chip”: Microfluidic impedance platform for antischistosomal drug discovery (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/infected-body-on-a-chip-microfluidic-impedance-platform-for-antischistosomal-drug-discovery
Many new methods in drug discovery originate from the field of microfluidics, which also include innovative methods to monitor the status of cells or tissues by means of electric impedance spectroscop
Ensuring the Efficacy of Mass Drug Administration Drugs for Soil-Transmitted Helminths (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/ensuring-the-efficacy-of-mass-drug-administration-drugs-for-soil-transmitted-helminths
The overall objective of the investment is to establish a surveillance system that globally monitors the eficacy of drugs and spread of AR in STH programs, and hence prevailing the success of MDA prog
Evaluation of the Papua New Guinea National Malaria Control Program, 2018-2020 (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/evaluation-of-the-papua-new-guinea-national-malaria-control-program-2018-2020
Papua New Guinea (PNG) has long been considered the country with the highest malaria transmission outside of sub-Saharan Africa. Over 90% of the approximately 8 million people are at risk of malaria i
PANACEA2 Genomics (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/panacea2-genomics
The PANACEA2 Consortium is testing new drugs and treatment regimens against tuberculisis (TB) in various African countries. Our role in this consortium is to use next-generation genome seqeuncing to s