dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
Pyrimidine metabolism is a major route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite
Optimized Malaria-antigens delivered by immunostimulating reconstituted influenza virosomes (Publications)
Malaria remains a serious cause of morbidity and mortality in millions of individuals each year. The development of widespread resistance of the parasite to drugs as well as resistance of the transmit
Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against <em>Clonorchis sinensis</em>: acomparative in... (Publications)
We comparatively assessed the in vivo efficacy of artemether, artesunate, praziquantel and tribendimidine against different stages of Clonorchis sinensis. Rats were infected with 40-50 C. sinensis met
Ultrastructural alterations in adult <em>Schistosoma mansoni</em> caused by artemether (Publications)
Progress has been made over the last decade with the development and clinical use of artemether as an agent against major human schistosome parasites. The tegument has been identified as a key target
Transmission electron microscopic observations on ultrastructural damage in juvenile <em>Schistosoma mansoni</em> caused by artemether (Publications)
Artemether, a derivative of the antimalarial artemisinin, has been shown to induce rapid and extensive alteration to the tegument of juvenile Schistosoma japonicum, S. mansoni and S. haematobium. Less