Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity (Publications)
Ancient Chinese herbal texts as far back as the 4th Century Zhou hou bei ji fang describe methods for the use of Qing Hao (Artemisia annua) for the treatment of intermittent fevers. Today, the A. annu
Residential black carbon exposure and circulating markers of systemic inflammation in elderly males: the normative aging study (Publications)
Background: Traffic-related particles (TRPs) are associated with adverse cardiovascular events. The exact mechanisms are unclear, but systemic inflammatory responses likely play a role.Objectives: We
Diagnostics are central for a truly holistic approach against intestinal parasitic diseases (Publications)
This is a perspectives piece on the central role of diagnostics for a truly holistic approach against gastrointestinal (GI) parasitic diseases. This article was motivated by a recent review in the Int
Association between long-term exposure to traffic-related air pollution and subclinical atherosclerosis: the REGICOR study (Publications)
Background: Epidemiological evidence of the effects of long-term exposure to air pollution on the chronic processes of atherogenesis is limited.Objective: We investigated the association of long-term
In silico ionomics segregates parasitic from free-living eukaryotes (Publications)
Ion transporters are fundamental to life. Due to their ancient origin and conservation in sequence, ion transporters are also particularly well suited for comparative genomics of distantly related spe
Sequence diversity in the <em>pe_pgrs</em> genes of <em>Mycobacterium tuberculosis</em> is independent of human T cell recognition (Publications)
The Mycobacterium tuberculosis genome includes the large family of pe_pgrs genes, whose functions are unknown. Because of precedents in other pathogens in which gene families showing high sequence var
Investigation of indolglyoxamide and indolacetamide analogues of polyamines as antimalarial and antitrypanosomal agents (Publications)
Pure compound screening has previously identified the indolglyoxy lamidospermidine ascidian metabolites didemnidine A and B (2 and 3) to be weak growth inhibitors of Trypanosoma brucei rhodesiense (IC
Cause-specific childhood mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites (Publications)
BACKGROUND: Childhood mortality, particularly in the first 5 years of life, is a major global concern and the target of Millennium Development Goal 4. Although the majority of childhood deaths occur i