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1. A pyridyl-furan series developed from the Open Global Health Library block red blood cell invasion and protein trafficking in <em>Plasmodium... (Publications)

   A pyridyl-furan series developed from the Open Global Health Library block red blood cell invasion and protein trafficking in <em>Plasmodium falciparum</em> through potential inhibition of the parasite's PI4KIIIB enzyme

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   discover new drug targets and to develop new medicines against these targets. We therefore screened the Open Global Health Library of Merck KGaA, Darmstadt, Germany, of 250 compounds against the asexual blood

2. Crisis management by HIV/AIDS non-governmental organisations in the post-Euromaidan Ukraine led to opening new horizons (Publications)

   Crisis management by HIV/AIDS non-governmental organisations in the post-Euromaidan Ukraine led to opening new horizons

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   Purpose Civil society played a significant role during and after the 2014 revolution in Ukraine, which led to the resignation of President Yanukovich and his government and triggered a series of polit

3. Cause of death estimation from verbal autopsies: is the open response redundant or synergistic? (Publications)

   Cause of death estimation from verbal autopsies: is the open response redundant or synergistic?

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   of the deceased. The VA includes both Closed Questions (CQs) with structured answer options, and an Open Response (OR) consisting of a free narrative of the events expressed in natural language and without

4. Screening open access compound libraries and repurposing drugs to identify and characterize new molecules active against schistosomiasis and other... (Publications)

   Screening open access compound libraries and repurposing drugs to identify and characterize new molecules active against schistosomiasis and other helminthiases

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   hic early drug development with a strong emphasis on schistosomiasis. Activity-based screening of open access libraries has identified new potent antischistosomal molecules. Investigating the activity [...] that could be used for further compound development. Finally, this work highlights the importance of open access libraries, drug repurposing and non-profit product development partnerships to stimulate the

5. Safety and efficacy of oral fexinidazole in children with <em>gambiense </em>human African trypanosomiasis: a multicentre, single-arm, open-label,... (Publications)

   Safety and efficacy of oral fexinidazole in children with <em>gambiense </em>human African trypanosomiasis: a multicentre, single-arm, open-label, phase 2-3 trial

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   disease stages of gambiense human African trypanosomiasis. METHODS: We did a multicentre, single-arm, open-label, phase 2-3 trial at eight district hospitals in the Democratic Republic of the Congo. We recruited

6. Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project (Publications)

   Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project

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7. Strikingly decreased community-acquired pneumonia admissions in children despite open schools and day-care facilities in Switzerland (Publications)

   Strikingly decreased community-acquired pneumonia admissions in children despite open schools and day-care facilities in Switzerland

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8. Oral fexinidazole for stage 1 or early stage 2 African <em>Trypanosoma brucei gambiense</em> trypanosomiasis: a prospective, multicentre, open-label,... (Publications)

   Oral fexinidazole for stage 1 or early stage 2 African <em>Trypanosoma brucei gambiense</em> trypanosomiasis: a prospective, multicentre, open-label, cohort study

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   the safety and efficacy of fexinidazole in early g-HAT. METHODS: In this prospective, multicentre, open-label, single-arm cohort study, patients with stage 1 or early stage 2 g-HAT were recruited from eight

9. Ultrasononography in managing extrapulmonary tuberculosis: a randomized, controlled, parallel, superiority, open-label trial (Publications)

   Ultrasononography in managing extrapulmonary tuberculosis: a randomized, controlled, parallel, superiority, open-label trial

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   BACKGROUND: Patients with suspected extrapulmonary tuberculosis are often treated empirically. We hypothesized that extended focused assessment with sonography for human immunodeficiency virus (HIV) a

10. Post-exposure lopinavir-ritonavir prophylaxis versus surveillance for individuals exposed to SARS-CoV-2: the COPEP pragmatic open-label, cluster... (Publications)

    Post-exposure lopinavir-ritonavir prophylaxis versus surveillance for individuals exposed to SARS-CoV-2: the COPEP pragmatic open-label, cluster randomized trial

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    (LPV/r) was repurposed as a potential PEP agent against COVID-19. Methods: We conducted a pragmatic open-label, parallel, cluster-randomised superiority trial in four sites in Switzerland and Brazil between