Determinants of the cost-effectiveness of intermittent preventive treatment for malaria in infants and children (Publications)
seasonality, proportions of malaria fevers treated and drug characteristics. METHODS: We use a dynamic, individual-based simulation model of Plasmodium falciparum malaria epidemiology, antimalarial drug [...] preventive treatment in infants (IPTi) and children (IPTc) have shown promising results in reducing malaria episodes but with varying efficacy and cost-effectiveness. The effects of different intervention [...] g and more expensive drugs, high frequencies of drug resistance and high levels...
Safety of falciparum malaria diagnostic strategy based on rapid diagnostic tests in returning travellers and migrants: a retrospective study (Publications)
developed severe malaria while 6/137 of both RDT and BS positive did so. The use of RDT allowed a reduction of a median of 2.1 hours to get a first malaria test result.CONCLUSIONS: A malaria diagnostic strategy [...] tests for malaria (RDT) allow accurate diagnosis and prompt treatment. Validation of their usefulness in travellers with fever was needed. The safety of a strategy to diagnose falciparum malaria based on [...] those, 2/2028 (0.1%) developed uncomplicated malaria with both RDT and BS...
Experience and challenges from clinical trials with malaria vaccines in Africa (Publications)
clinical trials and malaria control programmes as part of the Global Malaria Action Plan (GMAP). GMAP outlined and support global strategies toward the elimination and eradication of malaria in many areas, [...] Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort [...] Despite this, there is currently no licensed malaria vaccine. Researchers,...
Simulation of the cost-effectiveness of malaria vaccines (Publications)
vaccination over 50% often exceed the benefits. CONCLUSION: The simulations indicate malaria vaccines might be efficient malaria control interventions, and that both transmission setting and vaccine delivery [...] BACKGROUND: A wide range of possible malaria vaccines is being considered and there is a need to identify which vaccines should be prioritized for clinical development. An important element of the information [...] individual-based stochastic model for the natural history and...
<em>Anopheles plumbeus</em> (Diptera: Culicidae) in Europe: a mere nuisance mosquito or potential malaria vector? (Publications)
of humans between Europe and malaria endemic countries and changes in environment and climate, these data strongly suggest that An. plumbeus could act as a vector for malaria and thus significantly contribute [...] to increasing the malaria transmission risk in Central-Western Europe. In locations showing high vulnerability to the presence of gametocyte carriers, the risk of transmission of malaria by An. plumbeus [...] ABSTRACT: BACKGROUND: Anopheles plumbeus has been recognized as a minor...
Quantifying behavioural interactions between humans and mosquitoes: Evaluating the protective efficacy of insecticidal nets against malaria... (Publications)
ABSTRACT: BACKGROUND: African malaria vectors bite predominantly indoors at night so sleeping under an Insecticide-Treated Net (ITN) can greatly reduce malaria risk. Behavioural adaptation by mosquitoes [...] allow vector mosquitoes to bite outside of peak sleeping hours and undermine efficacy of this key malaria prevention measure. METHODS: High coverage with largely untreated nets has been achieved in the Kilombero [...] peak sleeping hours, respectively. ITNs consistently conferred > 70%...
Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets (Publications)
BACKGROUND: Malaria prevention in Africa merits particular attention as the world strives toward a better life for the poorest. Insecticide-treated nets (ITNs) represent a practical means to prevent malaria in [...] targets for ITN coverage beyond vulnerable groups. METHODS AND FINDINGS: Using field-parameterized malaria transmission models, we show that high (80% use) but exclusively targeted coverage of young children
A virosomal malaria peptide vaccine elicits a long-lasting sporozoite-inhibitory antibody response in a phase 1a clinical trial (Publications)
CSP-specific antibodies elicited in this phase 1a trial. METHODOLOGY/PRINCIPAL FINDINGS: 46 healthy malaria-naive adults were immunized with virosomal formulations of two peptide-phosphatidylethanolamine
From strategy development to routine implementation: the cost of Intermittent Preventive Treatment in Infants for malaria control (Publications)
Saharan Africa. Intermittent Preventive Treatment in infants (IPTi) is a promising new tool for malaria control. Although efficacy information is available for many interventions, there is a dearth of
Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? (Publications)
BACKGROUND: The most common pesticide products for controlling malaria-transmitting mosquitoes combine two distinct modes of action: 1) conventional insecticidal activity which kills mosquitoes exposed [...] mosquitoes to non-users rather than killing them outright. METHODS: A process-explicit model of malaria transmission is described which captures the sequential interaction between deterrent and toxic actions
