Malaria intervention scale-up in Africa: effectiveness predictions for health programme planning tools, based on dynamic transmission modelling (Publications)
(IRS), management of uncomplicated malaria cases (CM) and seasonal malaria chemoprophylaxis (SMC) over a 10-year horizon, over a range of settings with stable endemic malaria. Generalized linear regression [...] intervention impact, to inform a malaria module in the Spectrum health programme planning tool. METHODS: The dynamic Plasmodium falciparum transmission model OpenMalaria was used to simulate health effects [...] entail a partial rebound in malaria mortality among people above 5 years of...
Susceptibility of <em>Anopheles gambiae</em> to insecticides used for malaria vector control in Rwanda (Publications)
a major threat to the gains made in malaria control. To monitor the presence and possible emergence of resistance against a variety of insecticides used for malaria control in Rwanda, nationwide insecticide [...] using the synergist PBO. CONCLUSION: This is the first nationwide study of insecticide resistance in malaria vectors in Rwanda. It shows the gradual increase of insecticide resistance to pyrethroids (lambd [...] testing and implement an insecticide resistance management strategy to...
Nouvelles approches pour la prévention de la malaria chez le voyageur (Publications)
Malaria is declining in many tropical countries. This reduction challenges our usual preventive strategies. In moderate to low risk areas, the Swiss guidelines recommend a stand-by emergency treatment [...] making through three clinical studies. The first showed that travelers visiting moderate to low risk malaria areas prefer a standby emergency treatment rather than chemoprophylaxis. The second study investigates
Sensitive and accurate quantification of human malaria parasites using droplet digital PCR (ddPCR) (Publications)
of parasite density in the human host is essential for understanding the biology and pathology of malaria. Semi-quantitative molecular methods are widely applied, but the need for an external standard curve
Mosquito behavior change after distribution of bednets results in decreased protection against malaria exposure (Publications)
efficacy of vector control in reducing malaria transmission. Methods.: In this study, we quantified human exposure to both bites and infective bites of a major malaria vector in Papua New Guinea over the [...] the course of 4 years surrounding nationwide bednet distribution. We also quantified malaria infection prevalence in the human population during the same time period. Results.: We observed a shift in mosquito [...] period and was lowest in the adult population, who may be an important...
Outdoor malaria transmission risks and social life: a qualitative study in South-Eastern Tanzania (Publications)
BACKGROUND: Behaviour changes in mosquitoes from indoor to outdoor biting result in continuing risk of malaria from outdoor activities, including routine household activities and occasional social and cultural [...] of various social and cultural gatherings that incidentally expose people to mosquito bites and malaria infection. RESULTS: Religious, cultural and social gatherings involving the wider community are conducted [...] work towards elimination. Focusing on single interventions will not...
Identifying key factors of the transmission dynamics of drug-resistant malaria (Publications)
Development of resistance to malaria treatments remains a great threat to continued malaria burden reduction and elimination. Quantifying the impact of key factors which increase the emergence and spread