SAR of a new antischistosomal urea carboxylic acid (Publications)
Urea carboxylic acids, products of aryl hydantoin hydrolysis, were recently identified as a new antischistosomal chemotype. We now describe a baseline structure-activity relationship (SAR) for this co
The promise, problems and pitfalls of mass drug administration for malaria elimination: a qualitative study with scientists and policymakers (Publications)
Background: The emergence of artemisinin resistance in the Greater Mekong Subregion (GMS) has prompted urgent containment measures. One possible approach is mass drug administration (MDA). This articl
Antimalarial lead-optimization studies on a 2,6-imidazopyridine series within a constrained chemical space to circumvent atypical dose-response curves... (Publications)
A lead-optimization program around a 2,6-imidazopyridine scaffold was initiated based on the two early lead compounds, 1 and 2, that were shown to be efficacious in an in vivo humanized Plasmodium fal
Effect of a 20-week physical activity intervention on selective attention and academic performance in children living in disadvantaged neighborhoods:... (Publications)
OBJECTIVES: To evaluate the effect of a 20-week school-based physical activity intervention program on academic performance and selective attention among disadvantaged South African primary school chi
Marginal structural models and other analyses allow multiple estimates of treatment effects in randomized clinical trials: meta-epidemiological... (Publications)
OBJECTIVES: To determine how marginal structural models (MSMs), which are increasingly used to estimate causal effects, are used in randomized clinical trials (RCTs) and compare their results with tho