Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
Amodiaquine plus artesunate is the recommended antimalarial treatment in many malaria-endemic countries. However, pediatric doses are largely based on a linear extrapolation from adult doses. We poole
Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions (Publications)
Objectives: We evaluated whether dried blood spots (DBS) are suitable to monitor combined ART when samples are collected in rural Tanzania and transported over a long distance to a specialized bioanal
The importance of dog population contact network structures in rabies transmission (Publications)
Canine rabies transmission was interrupted in N'Djamena, Chad, following two mass vaccination campaigns. However, after nine months cases resurged with re-establishment of endemic rabies transmission
Loss of genomic diversity in a <em>Neisseria meningitidis</em> clone through a colonization bottleneck (Publications)
Neisseria meningitidis is the leading cause of epidemic meningitis in the 'meningitis belt' of Africa, where clonal waves of colonization and disease are observed. Point mutations and horizontal gene
Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal... (Publications)
Whole genome sequencing analysis of 100 Neisseria meningitidis serogroup A isolates has revealed that the csaABCD-ctrABCD-ctrEF capsule polysaccharide synthesis locus represents a spontaneous point mu
Sachet water quality and product registration: a cross-sectional study in Accra, Ghana (Publications)
The study's objectives were to assess the extent to which packaged water producers follow product registration procedures and to assess the relationship between product registration and drinking water