Single-dose tafenoquine to prevent relapse of <em>Plasmodium vivax</em> malaria (Publications)
BACKGROUND: Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed "r
Early antischistosomal leads identified from<em> in vitro</em> and<em> in vivo</em> screening of the Medicines for Malaria Venture pathogen box (Publications)
As part of the control and elimination strategy of human schistosomiasis, preventive chemotherapy relies on a single drug, praziquantel. Facing an almost dry drug development pipeline, screening the P
Structure–activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of<em> Haemonchus contortus</em> development (Publications)
Recently, we discovered that the registered pesticide, tolfenpyrad (TFP), unexpectedly and potently inhibits the development of L4 larval stages of the parasitic nematode Haemonchus contortus with an