PCR correction strategies for malaria drug trials: updates and clarifications (Publications)
Malaria drug trials conducted in endemic areas face a major challenge in their analysis because it is difficult to establish whether parasitaemia in blood samples collected after treatment indicate drug [...] public and private bodies who are working on the development, deployment, and surveillance of new malaria drugs. We aim to promote discussion around these issues and argue for the adoption of improved s
Eave ribbons treated with transfluthrin can protect both users and non-users against malaria vectors (Publications)
treated with spatial repellents effectively prevent human exposure to outdoor-biting and indoor-biting malaria mosquitoes, and could constitute a scalable and low-cost supplement to current interventions, such [...] ribbons alone. CONCLUSION: Transfluthrin-treated eave ribbons protect both users and non-users against malaria mosquitoes indoors and outdoors. The mosquito-killing property of transfluthrin can magnify the communal
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (Publications)
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on [...] Altogether, these findings provide a mechanistic link between EVs and vascular dysfunction during malaria infection.
Malaria: «Einstein» und die Spritze der Hoffnung (Publications)
In Afrika läuft die weltweit erste Impfkampagne gegen Malaria. In Ghana, Malawi und Kenia werden bis 2022 gegen zwei Millionen Kleinkinder mit dem Vakzin «RTS’S» geimpft. «Einstein» hat die Entwicklung [...] begleitet. Die Langzeit-Dokumentation zeigt auf, wie schwierig der Weg zur ersehnten neuen Waffe gegen Malaria war. Die Schweiz spielte bei der Entwicklung des Impfstoffs eine tragende Rolle, doch die Testreihen [...] und echte Forschungspartnerschaft zwischen Nord und Süd möglich war. Die...
Mapping routine malaria incidence at village level for targeted control in Papua New Guinea (Publications)
Malaria surveillance and response-systems are essential for identifying the areas most affected by malaria and for targeting interventions and optimising resources. This study aimed to assess whether the
Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in... (Publications)
BACKGROUND: We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted
Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
protein 1 (HP1) is important for dynamically regulating its various functions. However, in the malaria parasite Plasmodium falciparum both the function of HP1 phosphorylation and the identity of the protein
Repeated mosquito net distributions, improved treatment, and trends in malaria cases in sentinel health facilities in Papua New Guinea (Publications)
RESULTS: Malaria incidence initially ranged from 20 to 115/1000 population; subsequent trends varied by site. Overall, LLIN distributions had a cumulative effect, reducing the number of malaria cases with [...] not ACT, were associated with reductions of malaria cases in a range of settings, but sustainability of the gains appear to depend on local factors. Malaria programmes covering diverse transmission settings [...] al nets (LLIN), improved diagnosis and artemisinin-based combination therapy...
Operational coverage and timeliness of reactive case detection for malaria elimination in Zanzibar, Tanzania (Publications)
Since 2012, the Zanzibar Malaria Elimination Program has been implementing reactive case detection (RACD). Health facility (HF) staff send individual malaria case notifications by using mobile phones, [...] triggering a review of HF records and malaria testing and treatment at the household level by a district malaria surveillance officer. We assessed the completeness and timeliness of this system, from [...] Zanzibar achieved high operational coverage, timeliness was suboptimal. Patients...
Severe outcomes of malaria in children under time-varying exposure (Publications)
Plasmodium falciparum severe malaria dataset to better understand the relationship between prevalence and incidence of malaria pediatric hospitalizations - a proxy of malaria severe outcomes- in East-Africa [...] In malaria epidemiology, interpolation frameworks based on available observations are critical for policy decisions and interpreting disease burden. Updating our understanding of the empirical evidence [...] dynamics, and subsequent protection patterns in children, substantially...