hERG,<em> Plasmodium</em> life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole (Publications)
Toward addressing the cardiotoxicity liability associated with the antimalarial drug astemizole (AST, hERG IC50 = 0.0042 μM) and its derivatives, we designed and synthesized analogues based on compoun
A new model for ranking schools of public health: the public health academic ranking (Publications)
Objectives: As there is no ranking designed for schools of Public Health, the aim of this project was to create one. Methods: To design the Public Health Academic Ranking (PHAR), we used the InCites B
Phylogenetic analysis of pyruvate-ferredoxin oxidoreductase, a redox enzyme involved in the pharmacological activation of nitro-based prodrugs in... (Publications)
The present frontrunners in the chemotherapy of infections caused by protozoa are nitro-based prodrugs that are selectively activated by PFOR-mediated redox reactions. This study seeks to analyze the
Child health and infection with low density (CHILD) malaria: a protocol for a randomised controlled trial to assess the long-term health and... (Publications)
INTRODUCTION: As malaria declines, low-density malaria infections (LMIs) represent an increasing proportion of infections and may have negative impacts on child health and cognition, necessitating dev
Gaussian process emulation to improve efficiency of computationally intensive multidisease models: a practical tutorial with adaptable R code (Publications)
BACKGROUND: The rapidly growing burden of non-communicable diseases (NCDs) among people living with HIV in sub-Saharan Africa (SSA) has expanded the number of multidisease models predicting future car
Effectiveness and acceptance of group therapy as a mental health intervention for people living with HIV in Africa - a scoping literature review (Publications)
Mental health problems are highly prevalent among people living with HIV/AIDS (PLWHA), yet mental health care in African countries is scarce. There is growing interest in understanding the effect of g
Rethinking the World Health Organization's leadership of global health governance and the global health surveillance systems (Publications)
Global health governance is a strategic priority for the World Health Organization (WHO), and the public health surveillance system (PHSS) is a fundamental element of the global health governance stru
Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity (Publications)
Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of
Feasibility of caregiver-administered anthropometric measurements of children under age 5: evidence from Zambia (Publications)
BACKGROUND: Accurate measurement of children's anthropometry is of central importance for the assessment of nutritional status as well as for the evaluation of nutrition-specific interventions. Social
Quantifying the impact of interventions against <em>Plasmodium vivax</em>: a model for country-specific use (Publications)
In order to evaluate the impact of various intervention strategies on Plasmodium vivax dynamics in low endemicity settings without significant seasonal pattern, we introduce a simple mathematical mode