Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening (Publications)
Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specific
Retrospective study on the usefulness of pulse oximetry for the identification of young children with severe illnesses and severe pneumonia in a rural... (Publications)
OBJECTIVE: This secondary analysis of data of a randomized controlled trial (RCT) retrospectively investigated the performance of pulse oximetry in identifying children with severe illnesses, with and
Insights into the genetic diversity of <em>Mycobacterium tuberculosis</em> in Tanzania (Publications)
BACKGROUND: Human tuberculosis (TB) is caused by seven phylogenetic lineages of the Mycobacterium tuberculosis complex (MTBC), Lineage 1-7. Recent advances in rapid genotyping of MTBC based on single
Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis (Publications)
Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious e
Novel 1-methyl-1 <em>H</em>-pyrazole-5-carboxamide derivatives with potent anthelmintic activity (Publications)
A phenotypic screen of two different libraries of small molecules against the motility and development of the parasitic nematode Haemonchus contortus led to the identification of two 1-methyl-1 H-pyra
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis (Publications)
Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of hig
Detection of dicistroviruses RNA in blood of febrile Tanzanian children (Publications)
Fever is the leading cause of paediatric outpatient consultations in Sub-Saharan Africa. Although most are suspected to be of viral origin, a putative causative pathogen is not identified in over a qu
Fecal colonization with multidrug-resistant <em>E. coli</em> among healthy infants in rural Bangladesh (Publications)
Third generation cephalosporins (3GC) are one of the main choices for treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. Due to their overuse, an increasing trend of r