Efficacy of single versus four repeated doses of praziquantel agains<em>t Schistosoma mansoni </em>infection in school-aged children from Côte... (Publications)
infection in school-aged children from Cote d'Ivoire, using two different diagnostic tests. METHODS: An open-label, randomized controlled trial was conducted from October 2018 to January 2019. School-aged children
Comparison of trial participants and open access users of a web-based physical activity intervention regarding adherence, attrition, and repeated... (Publications)
characteristics and adherence to the website (a) in the open access context over time from 2003 to 2009, and (b) between trial participants and open access users; and (2) to analyze attrition and predictors [...] the context (trial or open access) based on first visits and longest visits. Attrition and predictors of repeated participation were compared between trial participants and open access users. RESULTS: [...] years, and 74.9% were women. Comparing contexts, adherence was highest for...
Open source drug discovery: highly potent antimalarial compounds derived from the Tres Cantos arylpyrroles (Publications)
potential starting points for hit-to-lead campaigns. One such public set is explored, employing an open source research mechanism in which all data and ideas were shared in real time, anyone was able to [...] including activity within gametocyte and liver stage assays, but at the cost of low solubility. As an open source research project, unexplored avenues are clearly identified and may be explored further by
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond (Publications)
industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of [...] expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help
Whole genome sequencing of<em> Mycobacterium tuberculosis</em>: current standards and open issues (Publications)
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed from a research tool to a clinical application for the diagnosis and management of tuberculosis and in public health
A prospective, open-label, randomized trial of doxycycline versus azithromycin for the treatment of uncomplicated murine typhus (Publications)
evidence for optimum treatment duration. Azithromycin is a potential alternative. Methods: A prospective, open, randomised trial was conducted in non-pregnant, consenting inpatient adults with rapid diagnostic