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1. Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with <em>Opisthorchis... (Publications)

   Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with <em>Opisthorchis viverrini</em>: a randomised, exploratory, open-label, phase 2 trial

   Relevance:

   compared with that of praziquantel in patients with O viverrini infection. METHODS: We did a randomised open-label trial between February and April, 2010, in the Saysetha district, Attapeu Province, Laos. Eligible

2. Comparison of trial participants and open access users of a web-based physical activity intervention regarding adherence, attrition, and repeated... (Publications)

   Comparison of trial participants and open access users of a web-based physical activity intervention regarding adherence, attrition, and repeated participation

   Relevance:

   characteristics and adherence to the website (a) in the open access context over time from 2003 to 2009, and (b) between trial participants and open access users; and (2) to analyze attrition and predictors [...] the context (trial or open access) based on first visits and longest visits. Attrition and predictors of repeated participation were compared between trial participants and open access users. RESULTS: [...] years, and 74.9% were women. Comparing contexts, adherence was highest for...

3. Opening up the CPRs: Institutional change and the state in Kafue flats, Zambia (Publications)

   Opening up the CPRs: Institutional change and the state in Kafue flats, Zambia

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4. Managing research and surveillance projects in real-time with a novel open-source eManagement tool designed for under-resourced countries (Publications)

   Managing research and surveillance projects in real-time with a novel open-source eManagement tool designed for under-resourced countries

   Relevance:

   is lightweight and uses minimal internet resources. It was designed to be used with the open source software Open Data Kit (ODK). The users can easily configure odk_planner to meet their needs, and the [...] tracked sputum samples, and collected clinical and laboratory data. CONCLUSIONS: The user friendly, open source odk_planner is a simple, but multi-functional, Web-based eManagement tool with add-ons that

5. Open source drug discovery with the malaria box compound collection for neglected diseases and beyond (Publications)

   Open source drug discovery with the malaria box compound collection for neglected diseases and beyond

   Relevance:

   industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of [...] expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help

6. Open source drug discovery: highly potent antimalarial compounds derived from the Tres Cantos arylpyrroles (Publications)

   Open source drug discovery: highly potent antimalarial compounds derived from the Tres Cantos arylpyrroles

   Relevance:

   potential starting points for hit-to-lead campaigns. One such public set is explored, employing an open source research mechanism in which all data and ideas were shared in real time, anyone was able to [...] including activity within gametocyte and liver stage assays, but at the cost of low solubility. As an open source research project, unexplored avenues are clearly identified and may be explored further by

7. OpenHDS: Use of tablet computers in health and demographic surveillance (Publications)

   OpenHDS: Use of tablet computers in health and demographic surveillance

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8. Development of an open-source road traffic noise model for exposure assessment (Publications)

   Development of an open-source road traffic noise model for exposure assessment

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9. Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis... (Publications)

   Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pul

   Relevance:

   BACKGROUND: New antituberculosis regimens are urgently needed to shorten tuberculosis treatment. Following on from favourable assessment in a 2 week study, we investigated a novel regimen for efficacy

10. Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids (Publications)

    Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids

    Relevance:

    Phenotypic screening had successfully been used for hit generation, especially in the field of neglected diseases, in which feeding the drug pipeline with new chemotypes remains a constant challenge.