Nanomimics of host cell membranes block invasion and expose invasive malaria parasites (Publications)
The fight against most infectious diseases, including malaria, is often hampered by the emergence of drug resistance and lack or limited efficacies of vaccines. Therefore, new drugs, vaccines, or other [...] ligands involved in the initial attachment to host cells and they efficiently blocked reinvasion of malaria parasites after their egress from host cells in vitro. They exhibited efficacies of more than 2 orders [...] infective parasite. In the future, our strategy might offer interesting...
The impact of indoor residual spraying with malathion on malaria in refugee camps in eastern Sudan (Publications)
putative malaria patients were examined for parasites by PCR. Mortality rates in the 3 months following spraying were significantly lower in sprayed camps although differences in clinical malaria incidence
Low recovery rates stabilize malaria endemicity in areas of low transmission in coastal Kenya (Publications)
were commonplace and one of the major contributors for the stability of malaria in these sites. Using mechanistic models of malaria transmission, we found that the association of high prevalence and low [...] The prevalence of Plasmodium falciparum malaria in African communities can be high and stable even in areas of relatively low transmission where people expose to only a few infectious bites per year. We [...] low transmission could be due to low recovery rates. Therefore, significant...
Nonoperative treatment of splenic rupture in malaria tropica: review of literature and case report (Publications)
In many parts of the world malaria still is a major medical problem. Heavy international and transcontinental traveling carries malaria to non-endemic areas. Practicing physicians must be aware of the [...] the common, but also the rare and severe complications of malaria. During malaria changes in splenic structure can result in asymptomatic enlargement or complications such as hematoma formation, rupture, [...] threatening complication of Plasmodium vivax infection, but is rarely seen in...
Assessing the impact of malaria interventions on morbidity through a community-based surveillance system (Publications)
programme's impact on the community and health facility burden of malaria and to investigate the value of community-based reporting for routine malaria control programme monitoring. METHODS: This work was implemented [...] data on reported history of fever and severe malaria (convulsions) based on a 2-week recall. In parallel, we collected in-patient and out-patient fever and malaria diagnoses data from the 15 health facilities [...] l decline in the community burden of malaria morbidity between...
Safety and immunogenicity of RTS,S/AS02D malaria vaccine in infants (Publications)
BACKGROUND: The RTS,S/AS malaria vaccine is being developed for delivery through the World Health Organization's Expanded Program on Immunization (EPI). We assessed the feasibility of integrating RTS,S/AS02D [...] The detection of antibodies against Plasmodium falciparum circumsporozoite and efficacy against malaria infection were secondary objectives. RESULTS: At least one serious adverse event was reported in [...] dose of vaccine, the efficacy of the RTS,S/AS02D vaccine against first...
