Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased... (Publications)
shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could [...] could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination. METHODS: Using a standardized enzyme-linked immunosorbent assay, IgG antibodies [...] were associated with differential protection against naturally transmitted Pf...
Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated <em>Plasmodium falciparum</em> protein PFF0165c (Publications)
with its low polymorphism and association with clinical protection from malaria in humans, warrant its further development as a malaria vaccine candidate [...] We have identified new malaria vaccine candidates through the combination of bioinformatics prediction of stable protein domains in the Plasmodium falciparum genome, chemical synthesis of polypeptides [...] assays, and association of an antigen-specific antibody response with protection against clinical malaria. Within the predicted open...
Status febrilis mit Bewusstlosigkeit (Publications)
Cerebral malaria with Plasmodium vivax is uncommon. Normally Plasmodium falciparum is the cause of cerebral malaria. We report about a 18 year old patient from Pakistan with a history of intermittent fever [...] several months. The patient recovered within a few days; however prognosis can be severe when cerebral malaria is complicating the course of Plasmodium vivax infection
Till Voss (People)
https://www.swisstph.ch/en/staff/profile/people/till-voss
Till Voss, Unit Head, Malaria Gene Regulation (MPI) Till Voss is the Deputy Head of the Medical Parasitology and Infection Biology Department and leads the Malaria Gene Regulation Unit at Swiss TPH. He [...] that drive antigenic variation and sexual commitment in malaria parasites. Further activities include studies on gametocyte biology and malaria transmission-blocking drug discovery. Voss obtained his MSc
Medicines Implementation Research | Research at Swiss TPH (Page)
https://www.swisstph.ch/en/about/med/miru
Treatment of severe Malaria The serious disease malaria is a major burden in tropical and subtropical countries. Although great efforts have been made to control and eliminate malaria, more than 400,000 [...] Rectal Artesunate for Malaria Many children suffering from severe malaria live in poor rural communities with no access to health care. Where parenteral treatment of severe malaria is not available, the [...] Artesunate to Treat Severe Malaria The serious disease malaria is a high burden in...
Assessment of Anopheles stephensi surveillance needs, practices and priorities in Global Fund-supported countries in the Horn of Africa (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/assessment-of-anopheles-stephensi-surveillance-needs-practices-and-priorities-in-global-fund-supported-countries-in-the-horn-of-africa
efficient malaria vector, particularly in urban environments, appearing to quickly adapting itself to the local environment and surviving extremely high temperatures during the dry season, when malaria transmission [...] across sub-Saharan Africa, led the World WHO Global Malaria Programme to publish a vector alert noting the major potential threat the vector poses to malaria control and elimination in sub-Saharan Africa. The [...] In recent years, An. stephensi , an efficient urban malaria...
Use of insecticides in agriculture and the prevention of vector-borne diseases: population knowledge, attitudes, practices and beliefs in Elibou,... (Publications)
and beliefs (KAPB) pertaining to malaria are generally well described. However, little is known about population knowledge and awareness of insecticide resistance in malaria vectors. The aim of this study [...] resistance in malaria vectors, while people's knowledge about insecticide resistance was limited. There is a need to raise awareness in communities about the presence of resistance in malaria vectors and [...] study was to investigate KAPB related to insecticide resistance in malaria...
Claudia Daubenberger (People)
https://www.swisstph.ch/en/staff/profile/people/claudia-daubenberger
activities at Swiss TPH Analysis of human cellular immune responses to P. falciparum malaria antigens and in malaria vaccine trials Analysis of human cellular immune responses in M. ulcerans infection [...] falciparum Characterisation of cellular immune system of Aotus nancymaae, a nonhuman animal model for malaria vaccine development.
The empirical support for the radical cure strategy for eliminating <em>Plasmodium vivax</em> in China (Publications)
China is malaria-free, it is timely to consider how elimination of malaria was completed in People's Republic of China over the last 7 decades. Of the four widespread species of human malaria, Plasmodium [...] planning disease elimination in other malaria-endemic countries, with residual P. vivax malaria. METHODS: We collated data from both published and unpublished malaria parasite inoculation experiments conducted [...] (late spring) seasons had a pronounced effect on outbreaks during the mala...
Manuel Hetzel (People)
https://www.swisstph.ch/en/staff/profile/people/manuel-hetzel
research, and impact evaluations, with a focus on malaria. Dr. Hetzel’s current work includes investigating and improving the effectiveness of malaria control measures, such as vector control, case management [...] artesunate as pre-referral treatment of severe malaria in children in rural DR Congo, Nigeria and Uganda and conducted studies on the effectiveness of malaria reactive case detection in Zanzibar (Tanzania) [...] (Tanzania). Since 2008, he has been supporting the National Malaria...