Heterogeneity in P<em>lasmodium falciparum </em>whole sporozoite vaccine induced humoral immune responses and protection in African volunteers: the... (Publications)
geographical overlap of HIV and malaria, an effective malaria vaccine deployed in this population could possibly support the long-term objective of regional elimination of malaria by using mass vaccination. [...] and 405,000 deaths attributed to malaria. New tools such as efficacious vaccines, better drugs and diagnostics are needed to supplement the current malaria control tools that rest mainly on vector control [...] against malaria induced by these whole sporozoite based vaccines varies...
The relative roles of ANC and EPI in the continuous distribution of LLINs: a qualitative study in four countries (Publications)
through EPI because of a) stronger linkages and involvement between malaria and reproductive health programmes, as compared to malaria and EPI, and b) more complete programme monitoring for ANC-based d [...] Background: The continuous distribution of long-lasting insecticidal nets (LLINs) for malaria prevention, through the antenatal care (ANC) and the Expanded Programme on Immunizations (EPI), is recommended [...] sub-national, and facility-level health staff, and were selected to capture a...
Spatial effects on the multiplicity of <em>Plasmodium falciparum</em> infections (Publications)
homogeneous transmission used in mathematical transmission models for malaria. In the present study an individual-based mathematical malaria transmission model that incorporates multiple parasite clones, variable [...] prevalence or multiplicity of infection (MOI). In traditionally highly malaria endemic regions where most of the population harbours malaria parasites, humans are often infected with multiple parasite clones [...] As malaria is being pushed back on many frontiers and global case...
Reduction in the proportion of fevers associated with <em>Plasmodium falciparum</em> parasitaemia in Africa: a systematic review (Publications)
BACKGROUND: Malaria is almost invariably ranked as the leading cause of morbidity and mortality in Africa. There is growing evidence of a decline in malaria transmission, morbidity and mortality over the [...] presenting with a syndrome of 'presumptive malaria', 3) numerators (number of parasitologically confirmed cases) and denominators (total number of presumptive malaria cases) available, 4) good quality microscopy [...] However, there is still doubt whether this decline is reflected in a...
Pyrimethamine-resistant <em>Plasmodium falciparum</em> parasites among Tanzanian children: a facility-based study using the polymerase chain reaction (Publications)
of the 21 children with clinical malaria had pyrimethamine-resistant parasites. Currently, sulfadoxine-pyrimethamine is considered a potential first-line drug for malaria treatment in most African countries [...] used to estimate the proportion of pyrimethamine-resistant parasites in 101 children reporting with malaria at the hospital in Ifakara, a town in southern Tanzania. The method is based on the observation that [...] suggest that although sulfadoxine-pyrimethamine could still be effective...
High sensitivity detection of <em>Plasmodium</em> species reveals positive correlations between infections of different species, shifts in age... (Publications)
Plasmodium vivax and Plasmodium malariae. The development of a high-throughput molecular species diagnostic assay now enables routine PCR-based surveillance of malaria infections in large field and in [...] falciparum, P. vivax, P. malariae and Plasmodium ovale were observed in LDR-FMA compared to LM diagnosis (p < 0.001). Increases were particularly pronounced for P. malariae (3.9% vs 13.4%) and P. ovale [...] molecular diagnosis reveals patterns of malaria risk that are significantly...
Nicolas Brancucci Appointed Professor at the University of Basel (News)
https://www.swisstph.ch/en/news/news-detail/news/nicolas-brancucci-appointed-professor-at-the-university-of-basel
on the process of malaria transmission stage formation. Brancucci will lead a new unit at Swiss TPH called "Malaria Host Interactions". The unit studies the way in which the malaria parasite P. falciparum [...] Basel, where he investigated epigenetic mechanisms controlling antigenic variation of the human malaria parasite Plasmodium falciparum . He then worked as a postdoctoral fellow in Boston (Harvard T. H
High levels of genetic diversity of <em>Plasmodium falciparum</em> populations in Papua New Guinea despite variable infection prevalence (Publications)
obstacle to malaria control. Here, we investigate the relationship between local variation in malaria epidemiology and parasite genetic diversity in Papua New Guinea (PNG). Cross-sectional malaria surveys [...] surveys were performed in 14 villages spanning four distinct malaria-endemic areas on the north coast, including one area that was sampled during the dry season. High-resolution msp2 genotyping of 2,147 blood
Aktueller Malariaschutz bei Kurzzeitaufenthalt (Publications)
average of 800 malaria cases are recorded annually in Germany. One person in a hundred dies of the disease. Travel advice given by experienced physicians is essential to raise awareness of malaria risk in endemic [...] endemic areas. Rational mosquito protection on skin and textiles reduces the risk of malaria and other arthropod-transmitted diseases (e. g. dengue fever). Regular intake of an antimalarial drugs to suppress [...] doctor after taking the SET as quickly as possible. These elements...
New Antimalarial Drug Shows Promise (News)
https://www.swisstph.ch/en/news/news-detail/news/new-antimalarial-drug-shows-promise
Medicines for Malaria Venture (MMV), the Swiss Tropical and Public Health Institute (Swiss TPH) and other international researchers. "The ability of MMV048 to block all life-cycle stages of the malaria parasite [...] history in diseases of poverty. Malaria research has been a core focus since the institute's foundation in 1943. Today, some 200 specialists work on various aspects of malaria in Basel and abroad. Activities [...] parasite from person to person, suggests that this compound could...