Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes (Publications)
Praziquantel (PZQ) is the only available drug to treat schistosomiasis, and since its large scale use might be associated with the onset of resistance, new antischistosomal drugs should be developed.
School distribution as keep-up strategy to maintain universal coverage of long-lasting insecticidal nets: implementation and results of a program in... (Publications)
Tanzania successfully scaled up coverage of long-lasting insecticidal nets (LLINs) through mass campaigns. To sustain these gains, a school-based approach was piloted in the country's Southern Zone st
Successful comeback of the single-dose live oral cholera vaccine CVD 103-HgR (Publications)
Effective and easy to administer cholera vaccines are in need more than ever, for at risk populations and travellers alike. In many parts of the world cholera is still endemic, causing outbreaks and c
Evaluation of the in vivo activity of tribendimidine against <em>Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis,</em> and... (Publications)
We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of
Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with <em>Opisthorchis... (Publications)
BACKGROUND: Praziquantel is the only drug available for treatment of Opisthorchis viverrini, although in-vivo studies point to activity of mefloquine, artesunate, and tribendimidine against this liver
PCR diagnosis of <em>Opisthorchis viverrini</em> and <em>Haplorchis taichui</em> infections in a Lao community in an area of endemicity and comparison... (Publications)
Opisthorchiasis is a major public health problem in Southeast Asia. Affected individuals often have mixed infections with the liver fluke Opisthorchis viverrini and minute intestinal flukes such as Ha
Social and cultural determinants of anticipated acceptance of an oral cholera vaccine prior to a mass vaccination campaign in Zanzibar (Publications)
Despite improvements in sanitation and water supply, cholera remains a serious public health burden. Vaccination is included among recommendations for cholera control. Cultural concepts of illness are