Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...
Antimalarial Drug Screening (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/antimalarial-drug-screening
performed by Medicines for Malaria Venture in 2009 and showed that OZ439 is well tolerated at all dose levels. So called 'proof of concept' phase II clinical trials with malaria patients showed that the [...] Our mandate with Medicines for Malaria Venture in Geneva comprises exploratory work on novel compounds from various sources. The goal is to identify novel chemical entities showing antimalarial activity [...] during the last decade is that such novel compounds can ultimately become part of...
Pre-referral rectal artesunate: no cure for unhealthy systems (Publications)
rectal artesunate in settings where malaria mortality remains high. Without improving the entire continuum of care, children will continue to die from severe malaria and promising interventions will fail [...] Pre-referral rectal artesunate suppositories can save the lives of children with severe malaria if patients receive adequate post-referral care. A multi-country randomised controlled trial reporting on [...] In October, 2022, we reported on the findings of the Community Access to Rectal...
Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...
Molecular assays for antimalarial drug resistance surveillance: a target product profile (Publications)
Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance [...] in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination [...] techniques can be standardised, and identify the requirements for...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
known as MMV1557817, and show that it targets multiple stages of the malaria parasite lifecycle, is active in a preliminary mouse malaria model, and has a novel mechanism of action. Excitingly, resistance [...] To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor [...] digestion in asexual parasites. MMV1557817 can kill sexual-stage P....
Repeated mass distributions and continuous distribution of long-lasting insecticidal nets: modelling sustainability of health benefits from mosquito... (Publications)
LLIN distribution were also examined. METHODS: Dynamic simulations of malaria in humans and mosquitoes were run on the OpenMalaria platform, using stochastic individual-based simulation models. LLINs were [...] BACKGROUND: Stagnating funds for malaria control have spurred interest in the question of how to sustain the gains of recent successes with long-lasting insecticidal nets (LLINs) and improved case management [...] management (CM). This simulation study examined the malaria transmission...
Claudia Daubenberger Appointed Professor at the University of Basel (News)
https://www.swisstph.ch/en/news/news-detail/news/claudia-daubenberger-appointed-professor-at-the-university-of-basel
the Faculty of Science and the Faculty of Medicine. Daubenberger’s research focuses on evaluating malaria vaccine development approaches in sub-Saharan Africa and on understanding the immunology of host-pathogen [...] populations. “Claudia Daubenberger’s research has deepened our understanding of immune responses against malaria and other infectious diseases of poverty, which provides a foundation to develop markers for protection [...] will further intensify research at the interface of...
Phase 1 study in Tanzania to evaluate the safety and immunogenicity of BSPZV1 - a vaccine against Plasmodium falciparum sporozoite (PfSPZ) (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/phase-1-study-in-tanzania-to-evaluate-the-safety-and-immunogenicity-of-bspzv1-a-vaccine-against-plasmodium-falciparum-sporozoite-pfspz
Vaccine) in Tanzanian adults Malaria is one of the most severe diseases in tropical countries. During the last decade, great effort has led to success in controlling malaria transmission, morbidity and [...] and mortality. Nevertheless, still around 660 000 people die due to malaria infection per year. For further reduction and, ideally, to gain elimination of this of this burden, a vaccine is crucial. Since [...] well as induction of immune response. Afterwards, protective efficacy is tested by...