Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age (Publications)
BACKGROUND: Plasmodium falciparum malaria is a pressing global health problem. A previous study of the malaria vaccine RTS,S (which targets the circumsporozoite protein), given with an adjuvant system [...] system (AS02A), showed a 30% rate of protection against clinical malaria in children 1 to 4 years of age. We evaluated the efficacy of RTS,S given with a more immunogenic adjuvant system (AS01E) in children [...] completed the study procedures according to the protocol, the cumulative number...
Public health challenges and prospects for malaria control and elimination (Publications)
unprecedented efforts to control malaria, including renewed political and financial commitment and increased availability of both old and new strategies and tools. However, malaria still represents a major health [...] becoming increasingly crucial. Among other needs, common methodologies for estimating and tracking the malaria burden, new strategies to measure transmission, better understanding of immunity, and increased knowledge [...] only on Plasmodium falciparum but also and increasingly on...
The role of standby emergency medication for falciparum malaria: current opinion (Publications)
contracting malaria. This article was prepared following a meeting convened in London on Africa Malaria Day in 2002, in which the current opinions of experts in travel medicine and specifically malaria were discussed [...] Travellers to malaria-endemic destinations are at risk of significant disease and, sometimes, death. Current malaria protection strategies, including chemoprophylaxis, can never be completely effective [...] ate risk-benefit assessment. In very rare cases, inexplicable failure...
Determining important parameters in the spread of malaria through the sensitivity analysis of a mathematical model (Publications)
We perform sensitivity analyses on a mathematical model of malaria transmission to determine the relative importance of model parameters to disease transmission and prevalence. We compile two sets of baseline [...] as the prompt diagnosis and treatment of infectious individuals) can be successful in controlling malaria
Intermittent preventive treatment for malaria in infants: a decision-support tool for sub-Saharan Africa (Publications)
clinical cases of Plasmodium falciparum malaria, hospital admissions for infection with malaria parasites and malaria-associated death for different levels of malaria transmission intensity and seasonality [...] with the severity of the malaria outcome and with transmission intensity. The decision-support tool, available on the Internet, provides estimates of the percentage of malaria-associated deaths, hospi [...] effectiveness of IPTi varies with malaria transmission intensity and seasonality....
Pharmacotherapy, vaccines and malaria advice for HIV-infected travellers (Publications)
acquired during travel may be more frequent or severe. Challenges include the best options for malaria chemoprophylaxis, standby treatment and medical follow-up of the increasing number of HIV-infected
