Structure elucidation and antimalarial activity of apicidin F: an apicidin-like compound produced by <em>Fusarium fujikuroi</em> (Publications)
Apicidins are cyclic tetrapeptides with histone deacetylase inhibitory activity. Since their discovery in 1996 a multitude of studies concerning the activity against protozoa and certain cancer cell l
Not to be missed! Differential diagnoses of common dermatological problems in returning travellers (Publications)
After systemic febrile illnesses and diarrhoea, dermatological disorders are the third most frequent health problem of returning travellers consulting travel clinics. While most travel-related dermato
Sialic acid linkage in glycosphingolipids is a molecular correlate for trafficking and delivery of extracellular cargo (Publications)
Gangliosides, glycosphingolipids containing sialic acid moieties, are well known mediators of transmembrane signaling and endocytosis at the plasma membrane. However, little is known about their preci
Serum vitamin E concentrations at 1 year and risk of atopy, atopic dermatitis, wheezing, and asthma in childhood: the PASTURE study (Publications)
BACKGROUND: Prospective studies investigating the role of serum vitamin E concentrations during early life in the development of childhood allergies and asthma are limited. OBJECTIVE: To study the ass
Antitrypanosomal triterpenoid with an epsilon-lactone E-ring from <em>Salvia urmiensis</em> (Publications)
A new triterpenoid, urmiensolide (1), was isolated from Salvia urmiensis. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute con
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, there prodrugs and aza-analogues (Publications)
Fifty novel prodrugs and aza-analogues of 3,5-bis(4-amidinophenyl)isoxazole and its derivatives were prepared. Eighteen of the 24 aza-analogues exhibited IC50 values below 25nM against Trypanosoma bru
Mental health litaracy and the experience of depression in a community sample of gay men (Publications)
BACKGROUND: Gay men are at higher risk of suffering from a variety of psychiatric disorders, yet the mental health literacy of this population has remained largely unknown. METHODS: In 2007 and 2011,
Enantioselective synthesis of encecaline-derived potent antimalarial agents (Publications)
The high antiplasmodial activity of racemic benzylamines rac- and rac- stimulated the synthesis of pure enantiomers. Ellman's chiral sulfinamides (S)- and (R)- were used as chiral auxiliaries. Condens