Bedaquiline resistance in patients with drug-resistant tuberculosis in Cape Town, South Africa: a retrospective longitudinal cohort study (Publications)
BACKGROUND: Bedaquiline is a life-saving tuberculosis drug undergoing global scale-up. People at risk of weak tuberculosis drug regimens are a priority for novel drug access despite the potential sour
Improved latrines minimally impact <em>Schistosoma mekongi </em>transmission in Mekong islands (Publications)
Schistosoma mekongi and other intestinal helminth infections remain public health concerns in Lao People's Democratic Republic, especially in remote areas where access to sanitation is limited. We per
Prospects for dog rabies elimination in Nigeria by 2030 (Publications)
The attainment of the global target of zero dog-mediated human rabies by 2030 depends on functional rabies programmes. Nigeria, a rabies-endemic country, and the most populous country in Africa has a
High incidence of catheter-associated urinary tract infections and related antibiotic resistance in two hospitals of different geographic regions of... (Publications)
OBJECTIVE: Catheter-associated urinary tract infections (CAUTI) are common worldwide, but due to limited resources, its actual burden in low-income countries is unknown. Currently, there are gaps in k
Antibiotic use and consumption among medical patients of two hospitals in Sierra Leone: a descriptive report (Publications)
BACKGROUND: Although one of the main drivers of antimicrobial resistance is inappropriate antibiotic prescribing, there are limited resources to support the surveillance of antibiotic consumption in l
Metabolic characterization of <em>Leishmania major</em> infection in activated and nonactivated macrophages (Publications)
Infection with Leishmania spp. can lead to a range of symptoms in the affected individual, depending on underlying immune-metabolic processes. The macrophage activation state hereby plays a key role.
Metabolic, immune, and gut microbial signals mount a systems response to <em>Leishmania major</em> infection (Publications)
Parasitic infections such as leishmaniasis induce a cascade of host physiological responses, including metabolic and immunological changes. Infection with Leishmania major parasites causes cutaneous l
Metabolism of (<em>R</em>)-praziquantel versus the activation of a Parasite Transient Receptor Potential Melastatin ion channel (Publications)
Praziquantel (PZQ) is an essential anthelmintic drug recently established to be an activator of a Transient Receptor Potential Melastatin (TRPM(PZQ) ) ion channel in trematode worms. Bioinformatic, mu
Opportunities and challenges for decentralised clinical trials in sub-Saharan Africa: a qualitative study (Publications)
INTRODUCTION: Digital health has gained traction in research and development, and clinical decision support systems. The COVID-19 pandemic accelerated the adoption of decentralised clinical trials (DC