Effects of pyrethroid resistance on the cost effectiveness of a mass distribution of long-lasting insecticidal nets: a modelling study (Publications)
were used. The epidemiological models, implemented in OpenMalaria, were employed to study the impact of a single mass distribution of LLINs on malaria, both in terms of episodes prevented during the effective [...] BACKGROUND: The effectiveness of insecticide-treated nets in preventing malaria is threatened by developing resistance against pyrethroids. Little is known about how strongly this affects the effectiveness [...] levels of mortality in World Health Organization susceptibility tests,...
In Ivorian school-age children, infection with hookworm does not reduce dietary iron absorption or systemic iron utilization, whereas afebrile... (Publications)
in the afebrile malaria and hookworm groups were 12.9% and 32.2% (P < 0.001) before treatment and 23.6% and 30.0% (P = 0.113) after treatment, respectively. Treatment of afebrile malaria reduced inflammation [...] biomarkers, hepcidin, iron absorption, and utilization pre- and posttreatment in children with afebrile malaria, hookworm, and Schistosoma haematobium infection. DESIGN: Ivorian children aged 11-17 y with afebrile [...] limits conclusions. Geometric mean iron utilization ranged between...
Cause-specific mortality rates in sub-Saharan Africa and Bangladesh (Publications)
to noncommunicable diseases, and little malaria. HIV dominates in causes of mortality in the South African sites, which contrast with those in highly malaria endemic sites elsewhere in sub-Saharan Africa [...] diseases to mortality in sub-Saharan Africa are lower than has been previously suggested, while malaria is of relatively greater importance. CONCLUSION: The different patterns of mortality we identified
Community effectiveness of intermittent preventive treatment for infants (IPTi) in rural southern Tanzania (Publications)
Intermittent preventive treatment of malaria in infants (IPTi) with sulphadoxine-pyrimethamine shows evidence of efficacy in individually randomized, controlled trials. In a large-scale effectiveness study [...] selected divisions out of 24 in 6 districts of rural southern Tanzania. Coverage and effects on malaria and anemia were estimated through a representative survey in 2006 with 600 children aged 2-11 months [...] implemented on a large scale by existing health service staff, with a...
Molecular Immunology | Research at Swiss TPH (Page)
https://www.swisstph.ch/en/about/med/molecular-immunology
ch Key Projects Malaria P. falciparum : developing a synthetic subunit candidate vaccine Malaria is one of the most serious infectious diseases of humans. New approaches to combat malaria are urgently needed [...] efficacy of therapeutic interventions. This research focuses primarily on three infectious diseases: malaria due to Plasmodium falciparum, bacterial meningitis caused by Neisseria meningitides and Streptococcus [...] developing synthetic peptide structures that induce cross-reactive...
Do holes in long-lasting insecticidal nets compromise their efficacy against pyrethroid resistant <em>Anopheles gambiae</em> and <em>Culex... (Publications)
BACKGROUND: Resistance of malaria vectors to pyrethroids threatens the effectiveness of long-lasting insecticidal nets (LLINs) as a tool for malaria control. Recent experimental hut and observational studies [...] round holes. This study examines whether there is a threshold above which LLINs no longer reduce malaria transmission. METHODS: Intact and artificially-holed LLINs under three months old and untreated nets [...] evaluated in terms of protection against blood feeding, insecticidal...
Feasibility and acceptability of insecticide-treated plastic sheeting (ITPS) for vector control in Papua New Guinea (Publications)
sheeting (ITPS) as a malaria control intervention in Papua New Guinea (PNG). METHODS: ZeroVector(R) ITPS was installed in 40 homes across four study sites representing a cross section of malaria transmission risk [...] potential application of ITPS in the national malaria control programme. The positive study findings suggest a longer-term evaluation of this promising malaria control intervention warrants consideration
Spatially-explicit risk profiling of<em> Plasmodium falciparum</em> infections at a small scale: a geostatistical modelling approach (Publications)
BACKGROUND: There is a renewed political will and financial support to eradicate malaria. Spatially-explicit risk profiling will play an important role in this endeavour. Patterns of Plasmodium falciparum [...] falciparum infection prevalence were examined among schoolchildren in a highly malaria-endemic area. METHODS: A questionnaire was administered and finger prick blood samples collected from 3,962 children, aged [...] the questionnaire on children's socioeconomic status and the use of bed...
A review of the frequencies of <em>Plasmodium falciparum</em> Kelch 13 artemisinin resistance mutations in Africa (Publications)
failure, except for Rwanda. These mutations present a threat to malaria control across the continent, since the greatest burden of malaria remains in Africa. A rise in the frequency of these mutations and [...] Plasmodium falciparum Kelch 13 (Pfk13), 7 years ago has provided an invaluable tool for monitoring AR in malaria endemic countries. Molecular Pfk13 surveillance revealed the resistance foci in the Greater Mekong [...] and their spread would reverse the gains made in the reduction of malar...
Recalculating the net use gap: a multi-country comparison of ITN use versus ITN access (Publications)
treated nets is widely recognized as one of the main interventions to prevent malaria and high use rates are a central goal of malaria programs. The gap between household ownership of at least one ITN and population [...] within the household' as now recommended by Roll Back Malaria and the World Health Organization. Data from 41 Demographic Health Surveys (DHS) and Malaria Indicator Surveys (MIS) (2005-2012) in sub-Saharan